Cover Image

Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome

The purpose of this paper was to investigate the role of serum asymmetric dimethylarginine (ADMA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and identify its clinical significance in OSAHS related cardiovascular diseases. A total of 75 patients with OSAHS were enrolled and...

Full description

Saved in:
Bibliographic Details
Main Authors: Wang, Jinping, Yuan, Lijie, Zhang, Haixiang, Yun, Yonggang
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2020
Online Access:http://journalarticle.ukm.my/15632/1/21.pdf
http://journalarticle.ukm.my/15632/
http://www.ukm.my/jsm/malay_journals/jilid49bil7_2020/KandunganJilid49Bil7_2020.html
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-ukm.journal.15632
record_format eprints
spelling my-ukm.journal.156322020-11-11T16:49:28Z http://journalarticle.ukm.my/15632/ Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome Wang, Jinping Yuan, Lijie Zhang, Haixiang Yun, Yonggang The purpose of this paper was to investigate the role of serum asymmetric dimethylarginine (ADMA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and identify its clinical significance in OSAHS related cardiovascular diseases. A total of 75 patients with OSAHS were enrolled and divided into mild (n=25), moderate (n=27), and severe group (n=23) according to their apnea hypopnea index (AHI) and minimal oxygen saturation (SaO2 min), respectively. Thirty healthy individuals were enrolled as normal control. Serum ADMA was measured with enzyme-linked immunosorbent assay (ELISA). Nitric oxide (NO) level was assayed with colorimetric method. Nasal continuous positive airway pressure (nCPAP) treatment was performed to the patients, and the follow up lasted for 2 months. Serum ADMA level increased with the severity of patients. Serum NO level decreased with severity of patients. A negative correlation was noticed between serum NO and mean SaO2 (SaO2 mean) and minimal SaO2 (SaO2 min). Serum ADMA was positively correlated with AHI, tSaO2<90%, and morbidity of cardiovascular diseases. After nCPAP therapy, the serum ADMA level was remarkably decreased and NO was remarkably increased in patients with OSAHS. Serum ADMA may be correlated with OSAHS and OSAHS related cardiovascular diseases. Reducing the plasma ADMA level by nCPAP therapy can reduce the morbidity of OSAHS-related cardiovascular diseases. Penerbit Universiti Kebangsaan Malaysia 2020-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15632/1/21.pdf Wang, Jinping and Yuan, Lijie and Zhang, Haixiang and Yun, Yonggang (2020) Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome. Sains Malaysiana, 49 (7). pp. 1713-1718. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil7_2020/KandunganJilid49Bil7_2020.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The purpose of this paper was to investigate the role of serum asymmetric dimethylarginine (ADMA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and identify its clinical significance in OSAHS related cardiovascular diseases. A total of 75 patients with OSAHS were enrolled and divided into mild (n=25), moderate (n=27), and severe group (n=23) according to their apnea hypopnea index (AHI) and minimal oxygen saturation (SaO2 min), respectively. Thirty healthy individuals were enrolled as normal control. Serum ADMA was measured with enzyme-linked immunosorbent assay (ELISA). Nitric oxide (NO) level was assayed with colorimetric method. Nasal continuous positive airway pressure (nCPAP) treatment was performed to the patients, and the follow up lasted for 2 months. Serum ADMA level increased with the severity of patients. Serum NO level decreased with severity of patients. A negative correlation was noticed between serum NO and mean SaO2 (SaO2 mean) and minimal SaO2 (SaO2 min). Serum ADMA was positively correlated with AHI, tSaO2<90%, and morbidity of cardiovascular diseases. After nCPAP therapy, the serum ADMA level was remarkably decreased and NO was remarkably increased in patients with OSAHS. Serum ADMA may be correlated with OSAHS and OSAHS related cardiovascular diseases. Reducing the plasma ADMA level by nCPAP therapy can reduce the morbidity of OSAHS-related cardiovascular diseases.
format Article
author Wang, Jinping
Yuan, Lijie
Zhang, Haixiang
Yun, Yonggang
spellingShingle Wang, Jinping
Yuan, Lijie
Zhang, Haixiang
Yun, Yonggang
Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome
author_facet Wang, Jinping
Yuan, Lijie
Zhang, Haixiang
Yun, Yonggang
author_sort Wang, Jinping
title Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome
title_short Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome
title_full Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome
title_fullStr Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome
title_full_unstemmed Role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome
title_sort role of serum asymmetric dimethylarginine level in cardiovascular diseases early prognostic in patients with obstructive sleep apnea-hypopnea syndrome
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2020
url http://journalarticle.ukm.my/15632/1/21.pdf
http://journalarticle.ukm.my/15632/
http://www.ukm.my/jsm/malay_journals/jilid49bil7_2020/KandunganJilid49Bil7_2020.html
_version_ 1683231770920615936
score 13.211869

Similar Items