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STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour

Solitary fibrous tumour (SFT) is a fibrotic neoplasm, also previously designated as hemangiopericytoma. STAT6 is a protein for signal tranducers and activators of transcription (STAT) family which is involved in immune function and early cell growth. Oncogenic alteration of STAT6 plays an importa...

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Main Authors: Amizatul Aini S,, Nur Maya Sabrina TL,, Muhamad Fakhri MS,, Noraini MD,, Reena Rahayu Md Zain,
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2019
Online Access:http://journalarticle.ukm.my/15546/1/4_ms0265_pdf_97376.pdf
http://journalarticle.ukm.my/15546/
https://www.medicineandhealthukm.com/toc/14/2
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spelling my-ukm.journal.155462020-11-04T15:36:18Z http://journalarticle.ukm.my/15546/ STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour Amizatul Aini S, Nur Maya Sabrina TL, Muhamad Fakhri MS, Noraini MD, Reena Rahayu Md Zain, Solitary fibrous tumour (SFT) is a fibrotic neoplasm, also previously designated as hemangiopericytoma. STAT6 is a protein for signal tranducers and activators of transcription (STAT) family which is involved in immune function and early cell growth. Oncogenic alteration of STAT6 plays an important role for specific driver for tumour genesis of solitary fibrous tumour via NAB2-STAT6 fusion gene. The aim of the study was to compare and evaluate STAT6 expression between SFT and other soft tissue histological mimics. We evaluated a total of 30 cases material formalin fixed paraffin embedded tissue block previously diagnosed SFT cases (n=14) and soft tissue tumours mimic cases (n=16) over period of 15 years. Fourteen SFT cases (100%) showed nuclear expression of STAT6, which was diffuse and intense. All other tumour types were negative for STAT6, except for one case of dedifferentiated liposarcoma, one gastrointestinal stromal tumour and one spindle cell lipoma, which showed weak non-specific cytoplasmic staining. Nuclear STAT6 expression is useful and reliable as adjunctive marker for solitary fibrous tumour when the diagnosis is inconclusive by conventional methods. Pusat Perubatan Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15546/1/4_ms0265_pdf_97376.pdf Amizatul Aini S, and Nur Maya Sabrina TL, and Muhamad Fakhri MS, and Noraini MD, and Reena Rahayu Md Zain, (2019) STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour. Medicine & Health, 14 (2). pp. 41-49. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/14/2
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Solitary fibrous tumour (SFT) is a fibrotic neoplasm, also previously designated as hemangiopericytoma. STAT6 is a protein for signal tranducers and activators of transcription (STAT) family which is involved in immune function and early cell growth. Oncogenic alteration of STAT6 plays an important role for specific driver for tumour genesis of solitary fibrous tumour via NAB2-STAT6 fusion gene. The aim of the study was to compare and evaluate STAT6 expression between SFT and other soft tissue histological mimics. We evaluated a total of 30 cases material formalin fixed paraffin embedded tissue block previously diagnosed SFT cases (n=14) and soft tissue tumours mimic cases (n=16) over period of 15 years. Fourteen SFT cases (100%) showed nuclear expression of STAT6, which was diffuse and intense. All other tumour types were negative for STAT6, except for one case of dedifferentiated liposarcoma, one gastrointestinal stromal tumour and one spindle cell lipoma, which showed weak non-specific cytoplasmic staining. Nuclear STAT6 expression is useful and reliable as adjunctive marker for solitary fibrous tumour when the diagnosis is inconclusive by conventional methods.
format Article
author Amizatul Aini S,
Nur Maya Sabrina TL,
Muhamad Fakhri MS,
Noraini MD,
Reena Rahayu Md Zain,
spellingShingle Amizatul Aini S,
Nur Maya Sabrina TL,
Muhamad Fakhri MS,
Noraini MD,
Reena Rahayu Md Zain,
STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
author_facet Amizatul Aini S,
Nur Maya Sabrina TL,
Muhamad Fakhri MS,
Noraini MD,
Reena Rahayu Md Zain,
author_sort Amizatul Aini S,
title STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
title_short STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
title_full STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
title_fullStr STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
title_full_unstemmed STAT6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
title_sort stat6 is a useful immunohistochemical adjunct for the diagnosis of solitary fibrous tumour
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2019
url http://journalarticle.ukm.my/15546/1/4_ms0265_pdf_97376.pdf
http://journalarticle.ukm.my/15546/
https://www.medicineandhealthukm.com/toc/14/2
_version_ 1683231759208022016
score 13.211869

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