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Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review

Gelatin has been frequently used in tissue engineering scaffold due to its favorable biological properties in wound healing enhancement. Genipin, a natural compound derived from Gardenia plants, was shown to be effective in improving physicochemical characteristics of the gelatin scaffold. This sy...

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Main Authors: Muhammad Mior Amirul A,, Mohd Heikal Mohd Yunus,, MH Busra F,
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2019
Online Access:http://journalarticle.ukm.my/15543/1/1_ms0312_pdf_83629.pdf
http://journalarticle.ukm.my/15543/
https://www.medicineandhealthukm.com/toc/14/2
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spelling my-ukm.journal.155432020-11-04T15:28:45Z http://journalarticle.ukm.my/15543/ Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review Muhammad Mior Amirul A, Mohd Heikal Mohd Yunus, MH Busra F, Gelatin has been frequently used in tissue engineering scaffold due to its favorable biological properties in wound healing enhancement. Genipin, a natural compound derived from Gardenia plants, was shown to be effective in improving physicochemical characteristics of the gelatin scaffold. This systematic review reported the utility of genipin as a crosslinker in gelatin scaffold fabrication. Two electronic databases, namely Scopus and MEDLINE via Ebcoshost were searched for publication between January 1999 and December 2018, using the keywords ‘gelatin’ and ‘genipin’. Articles published in English, reporting the utility of genipin in the fabrication of gelatin sponge were included. The keywords search yielded 830 articles, in which 14 articles were selected and examined in this review. The result of the search provided input in terms of the optimum concentration, crosslinking temperature, and fabrication method of genipin to be used. From the literature, it was found that 0.5% is the optimum genipin concentration and 25˚C is the optimum crosslinking temperature. The result also revealed a gap in the knowledge regarding genipin crosslinker and justifies the need to create awareness of the utility of genipin as a gelatin scaffold crosslinker. The current review provides an extensive overview on the current knowledge on genipin crosslinking and be a guide to an optimal fabrication of the genipin-crosslinked gelatin scaffold. Pusat Perubatan Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15543/1/1_ms0312_pdf_83629.pdf Muhammad Mior Amirul A, and Mohd Heikal Mohd Yunus, and MH Busra F, (2019) Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review. Medicine & Health, 14 (2). pp. 1-16. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/14/2
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Gelatin has been frequently used in tissue engineering scaffold due to its favorable biological properties in wound healing enhancement. Genipin, a natural compound derived from Gardenia plants, was shown to be effective in improving physicochemical characteristics of the gelatin scaffold. This systematic review reported the utility of genipin as a crosslinker in gelatin scaffold fabrication. Two electronic databases, namely Scopus and MEDLINE via Ebcoshost were searched for publication between January 1999 and December 2018, using the keywords ‘gelatin’ and ‘genipin’. Articles published in English, reporting the utility of genipin in the fabrication of gelatin sponge were included. The keywords search yielded 830 articles, in which 14 articles were selected and examined in this review. The result of the search provided input in terms of the optimum concentration, crosslinking temperature, and fabrication method of genipin to be used. From the literature, it was found that 0.5% is the optimum genipin concentration and 25˚C is the optimum crosslinking temperature. The result also revealed a gap in the knowledge regarding genipin crosslinker and justifies the need to create awareness of the utility of genipin as a gelatin scaffold crosslinker. The current review provides an extensive overview on the current knowledge on genipin crosslinking and be a guide to an optimal fabrication of the genipin-crosslinked gelatin scaffold.
format Article
author Muhammad Mior Amirul A,
Mohd Heikal Mohd Yunus,
MH Busra F,
spellingShingle Muhammad Mior Amirul A,
Mohd Heikal Mohd Yunus,
MH Busra F,
Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
author_facet Muhammad Mior Amirul A,
Mohd Heikal Mohd Yunus,
MH Busra F,
author_sort Muhammad Mior Amirul A,
title Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
title_short Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
title_full Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
title_fullStr Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
title_full_unstemmed Genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
title_sort genipin-crosslinked gelatin scaffold in tissue engineering: a systematic review
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2019
url http://journalarticle.ukm.my/15543/1/1_ms0312_pdf_83629.pdf
http://journalarticle.ukm.my/15543/
https://www.medicineandhealthukm.com/toc/14/2
_version_ 1683231758774960128
score 13.211869

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