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Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell

Three triterpenoids, taraxerone (1) and 18-epi-taraxerol (2), and masticadienolic acid (3) were isolated for the first time from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum, respectively. Isolation of the compounds was achieved by various extraction and chromatography column techn...

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Main Authors: Achmad Zainuddin,, Sylvia Rachmawati Meilanie,, Darwati,, Kurniawan,, Nurlelasari,, Tati Herlina,, Saputra, Adrian Rizky, Al Anshori, Jamaludin, Tri Mayanti,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2020
Online Access:http://journalarticle.ukm.my/15389/1/3.pdf
http://journalarticle.ukm.my/15389/
http://www.ukm.my/jsm/english_journals/vol49num5_2020/contentsVol49num5_2020.html
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spelling my-ukm.journal.153892020-10-23T00:45:01Z http://journalarticle.ukm.my/15389/ Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell Achmad Zainuddin, Sylvia Rachmawati Meilanie, Darwati, Kurniawan, Nurlelasari, Tati Herlina, Saputra, Adrian Rizky Al Anshori, Jamaludin Tri Mayanti, Three triterpenoids, taraxerone (1) and 18-epi-taraxerol (2), and masticadienolic acid (3) were isolated for the first time from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum, respectively. Isolation of the compounds was achieved by various extraction and chromatography column techniques, while their chemical structures were elucidated based on spectroscopic data and literature comparison. Compounds 1, 2, and 3 were found to show inhibitory activity against MCF-7 breast cancer cells with IC50 values 792.9, 59.6, and 3.5 µM correspondingly. Penerbit Universiti Kebangsaan Malaysia 2020-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15389/1/3.pdf Achmad Zainuddin, and Sylvia Rachmawati Meilanie, and Darwati, and Kurniawan, and Nurlelasari, and Tati Herlina, and Saputra, Adrian Rizky and Al Anshori, Jamaludin and Tri Mayanti, (2020) Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell. Sains Malaysiana, 49 (5). pp. 989-994. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol49num5_2020/contentsVol49num5_2020.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Three triterpenoids, taraxerone (1) and 18-epi-taraxerol (2), and masticadienolic acid (3) were isolated for the first time from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum, respectively. Isolation of the compounds was achieved by various extraction and chromatography column techniques, while their chemical structures were elucidated based on spectroscopic data and literature comparison. Compounds 1, 2, and 3 were found to show inhibitory activity against MCF-7 breast cancer cells with IC50 values 792.9, 59.6, and 3.5 µM correspondingly.
format Article
author Achmad Zainuddin,
Sylvia Rachmawati Meilanie,
Darwati,
Kurniawan,
Nurlelasari,
Tati Herlina,
Saputra, Adrian Rizky
Al Anshori, Jamaludin
Tri Mayanti,
spellingShingle Achmad Zainuddin,
Sylvia Rachmawati Meilanie,
Darwati,
Kurniawan,
Nurlelasari,
Tati Herlina,
Saputra, Adrian Rizky
Al Anshori, Jamaludin
Tri Mayanti,
Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell
author_facet Achmad Zainuddin,
Sylvia Rachmawati Meilanie,
Darwati,
Kurniawan,
Nurlelasari,
Tati Herlina,
Saputra, Adrian Rizky
Al Anshori, Jamaludin
Tri Mayanti,
author_sort Achmad Zainuddin,
title Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell
title_short Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell
title_full Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell
title_fullStr Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell
title_full_unstemmed Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell
title_sort cytotoxic triterpenoids from the stem barks of dysoxylum arborescens and dysoxylum excelsum against mcf-7 breast cancer cell
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2020
url http://journalarticle.ukm.my/15389/1/3.pdf
http://journalarticle.ukm.my/15389/
http://www.ukm.my/jsm/english_journals/vol49num5_2020/contentsVol49num5_2020.html
_version_ 1681490388023508992
score 13.211869

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