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A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk

The endothelial nitric oxide synthase (eNOS) rs1799983 polymorphism is known to increase the risk towards stroke, but data is under-reported in Malaysian population. Therefore, this study sought to investigate this association in a Malaysian population and in a comprehensive meta-analysis. Genotypin...

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Main Authors: Phneh, KY, Chong, ETJ, Sybil Shah S,, Chia, YK, AG. Daud DM,, Jalil E,, Cheng, KCS, Lee, PC
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2019
Online Access:http://journalarticle.ukm.my/15218/1/10_ms0269_pdf_18512.pdf
http://journalarticle.ukm.my/15218/
http://www.medicineandhealthukm.com/toc/14/1
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spelling my-ukm.journal.152182020-09-21T07:03:41Z http://journalarticle.ukm.my/15218/ A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk Phneh, KY Chong, ETJ Sybil Shah S, Chia, YK AG. Daud DM, Jalil E, Cheng, KCS Lee, PC The endothelial nitric oxide synthase (eNOS) rs1799983 polymorphism is known to increase the risk towards stroke, but data is under-reported in Malaysian population. Therefore, this study sought to investigate this association in a Malaysian population and in a comprehensive meta-analysis. Genotyping of the eNOS rs1799983 polymorphism was performed for 241 Malaysians using a hydrolysis probe. Odd ratio with 95% confidence interval was calculated. Meta-analysis was conducted using the Comprehensive Meta-Analysis software ver. 2.2.064. A p-value less than 0.05 was considered statistically significant. Overall, our results showed that the presence of eNOS rs1799983-T allele increases the risk towards stroke, particularly in males, fast-food goers and Malaysian Chinese. The meta-analysis showed that the rs1799983 polymorphism is significantly associated with an increase ischemic stroke risk in the recessive and allelic models. After stratified with population, these associations remain significant in the Asian population but not in the Caucasian population. In summary, this study establishes a significant relationship between the eNOS rs1799983 polymorphism with gender, lifestyle and ethnicity differences towards stroke risk in the Malaysian population. In addition, our meta-analysis suggests that the eNOS rs1799983 polymorphism is associated with an increase risk of ischemic stroke. Pusat Perubatan Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15218/1/10_ms0269_pdf_18512.pdf Phneh, KY and Chong, ETJ and Sybil Shah S, and Chia, YK and AG. Daud DM, and Jalil E, and Cheng, KCS and Lee, PC (2019) A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk. Medicine & Health, 14 (1). pp. 118-134. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/14/1
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The endothelial nitric oxide synthase (eNOS) rs1799983 polymorphism is known to increase the risk towards stroke, but data is under-reported in Malaysian population. Therefore, this study sought to investigate this association in a Malaysian population and in a comprehensive meta-analysis. Genotyping of the eNOS rs1799983 polymorphism was performed for 241 Malaysians using a hydrolysis probe. Odd ratio with 95% confidence interval was calculated. Meta-analysis was conducted using the Comprehensive Meta-Analysis software ver. 2.2.064. A p-value less than 0.05 was considered statistically significant. Overall, our results showed that the presence of eNOS rs1799983-T allele increases the risk towards stroke, particularly in males, fast-food goers and Malaysian Chinese. The meta-analysis showed that the rs1799983 polymorphism is significantly associated with an increase ischemic stroke risk in the recessive and allelic models. After stratified with population, these associations remain significant in the Asian population but not in the Caucasian population. In summary, this study establishes a significant relationship between the eNOS rs1799983 polymorphism with gender, lifestyle and ethnicity differences towards stroke risk in the Malaysian population. In addition, our meta-analysis suggests that the eNOS rs1799983 polymorphism is associated with an increase risk of ischemic stroke.
format Article
author Phneh, KY
Chong, ETJ
Sybil Shah S,
Chia, YK
AG. Daud DM,
Jalil E,
Cheng, KCS
Lee, PC
spellingShingle Phneh, KY
Chong, ETJ
Sybil Shah S,
Chia, YK
AG. Daud DM,
Jalil E,
Cheng, KCS
Lee, PC
A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk
author_facet Phneh, KY
Chong, ETJ
Sybil Shah S,
Chia, YK
AG. Daud DM,
Jalil E,
Cheng, KCS
Lee, PC
author_sort Phneh, KY
title A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk
title_short A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk
title_full A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk
title_fullStr A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk
title_full_unstemmed A case-control study and meta-analysis of the association of eNOS rs1799983 SNP with stroke risk
title_sort case-control study and meta-analysis of the association of enos rs1799983 snp with stroke risk
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2019
url http://journalarticle.ukm.my/15218/1/10_ms0269_pdf_18512.pdf
http://journalarticle.ukm.my/15218/
http://www.medicineandhealthukm.com/toc/14/1
_version_ 1678593697596309504
score 13.211869

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