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Effects of melamine and cyanuric acid on renal function and structure in rats

Melamine has been used to increase the amount of measurable nitrogen which is a component of protein. The renal toxicity of melamine has been reported in infants and animals that consumed a mixture of melamine in their food products. This study aimed to investigate the effects of melamine on rat ren...

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Main Authors: Saranya Peerakietkhajorn,, Nawiya Huipao,, Siriphun Hiranyachattada,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:http://journalarticle.ukm.my/13895/1/18%20Saranya%20Peerakietkhajorn.pdf
http://journalarticle.ukm.my/13895/
http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
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spelling my-ukm.journal.138952020-01-10T08:49:34Z http://journalarticle.ukm.my/13895/ Effects of melamine and cyanuric acid on renal function and structure in rats Saranya Peerakietkhajorn, Nawiya Huipao, Siriphun Hiranyachattada, Melamine has been used to increase the amount of measurable nitrogen which is a component of protein. The renal toxicity of melamine has been reported in infants and animals that consumed a mixture of melamine in their food products. This study aimed to investigate the effects of melamine on rat renal function using clearance and histological techniques. Animals were divided into 3 groups: vehicle control, 400 mg/kg melamine and mixture of 400 mg/kg melamine and 400 mg/kg cyanuric acid (p.o., daily for three days). The results showed that blood urea nitrogen level significantly increased in the rats treated with the mixture of melamine and cyanuric acid. The urine flow rate, glomerular filtration rate, renal plasma flow and urinary sodium and potassium excretion rate significantly decreased when compared to vehicle control. These results suggested both glomeruli and renal tubules of rats treated with mixture of melamine and cyanuric acid were damaged. Histological study also confirmed these findings and showed significant glomerular atrophy and dilated renal tubules. Numerous clear brownish-yellow crystals were also found in the distal tubule, collecting tubule and papillary duct. However, rats solely treated with melamine showed no significant difference in renal function or structures. Penerbit Universiti Kebangsaan Malaysia 2019-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13895/1/18%20Saranya%20Peerakietkhajorn.pdf Saranya Peerakietkhajorn, and Nawiya Huipao, and Siriphun Hiranyachattada, (2019) Effects of melamine and cyanuric acid on renal function and structure in rats. Sains Malaysiana, 48 (8). pp. 1721-1728. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Melamine has been used to increase the amount of measurable nitrogen which is a component of protein. The renal toxicity of melamine has been reported in infants and animals that consumed a mixture of melamine in their food products. This study aimed to investigate the effects of melamine on rat renal function using clearance and histological techniques. Animals were divided into 3 groups: vehicle control, 400 mg/kg melamine and mixture of 400 mg/kg melamine and 400 mg/kg cyanuric acid (p.o., daily for three days). The results showed that blood urea nitrogen level significantly increased in the rats treated with the mixture of melamine and cyanuric acid. The urine flow rate, glomerular filtration rate, renal plasma flow and urinary sodium and potassium excretion rate significantly decreased when compared to vehicle control. These results suggested both glomeruli and renal tubules of rats treated with mixture of melamine and cyanuric acid were damaged. Histological study also confirmed these findings and showed significant glomerular atrophy and dilated renal tubules. Numerous clear brownish-yellow crystals were also found in the distal tubule, collecting tubule and papillary duct. However, rats solely treated with melamine showed no significant difference in renal function or structures.
format Article
author Saranya Peerakietkhajorn,
Nawiya Huipao,
Siriphun Hiranyachattada,
spellingShingle Saranya Peerakietkhajorn,
Nawiya Huipao,
Siriphun Hiranyachattada,
Effects of melamine and cyanuric acid on renal function and structure in rats
author_facet Saranya Peerakietkhajorn,
Nawiya Huipao,
Siriphun Hiranyachattada,
author_sort Saranya Peerakietkhajorn,
title Effects of melamine and cyanuric acid on renal function and structure in rats
title_short Effects of melamine and cyanuric acid on renal function and structure in rats
title_full Effects of melamine and cyanuric acid on renal function and structure in rats
title_fullStr Effects of melamine and cyanuric acid on renal function and structure in rats
title_full_unstemmed Effects of melamine and cyanuric acid on renal function and structure in rats
title_sort effects of melamine and cyanuric acid on renal function and structure in rats
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2019
url http://journalarticle.ukm.my/13895/1/18%20Saranya%20Peerakietkhajorn.pdf
http://journalarticle.ukm.my/13895/
http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
_version_ 1657565435569111040
score 13.211869

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