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The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma

The leaves of cassava are used as traditional medicine, to treat ringworm, tumor, abscess, conjunctivitis, sores, headaches, rheumatism and fever diseases in several countries. Phytochemical investigations showed that flavonoids and Rutin constituents of the cassava leaves, berths the need for data...

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Main Authors: Nugrahaningsih, WH, Fatimatuz Zahroh,, Lisdiana,, Ari Yuniastuti,, Rudyatmi, Ely
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:http://journalarticle.ukm.my/13893/1/16%20Nugrahaningsih%20WH.pdf
http://journalarticle.ukm.my/13893/
http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
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spelling my-ukm.journal.138932020-01-10T08:48:22Z http://journalarticle.ukm.my/13893/ The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma Nugrahaningsih, WH Fatimatuz Zahroh, Lisdiana, Ari Yuniastuti, Rudyatmi, Ely The leaves of cassava are used as traditional medicine, to treat ringworm, tumor, abscess, conjunctivitis, sores, headaches, rheumatism and fever diseases in several countries. Phytochemical investigations showed that flavonoids and Rutin constituents of the cassava leaves, berths the need for data as regards safety, effectiveness, toxicity and pharmacokinetics for its usage as herbal medicine. The purpose of this research was to observe pharmacokinetic parameters of Rutin in rat plasma, after oral administration of cassava leaves extract. Pharmacokinetics indicators for absorption was (Cmax, tmax, and AUC0-24h), while elimination was (Ke and t1/2). 14 healthy male Wistar rats were divided into 7 groups (each group with 2 rats), after which a single dose (600 mg) of cassava leaves extract was given orally. Thereafter, blood samples of the wistar rats were collected and separated at different time intervals (0; 0.5; 1; 2; 4; 6; 12; and 24 h). Using HPLC-UV-VIS method, the resulting plasma was analyzed for Rutin concentration. The analysis showed Rutin concentration at 0 mg/mL (0 h), 0.151 mg/mL (0.5 h), 0.176 mg/mL (1 h), 0.18 mg/mL (2 h), 0.184 mg/mL (4 h), 0.163 mg/mL (6 h), 0.15 mg/mL (12 h) and 0.1225 mg/mL (24 h). The main pharmacokinetic parameters were; Cmax 0.184 mg/mL recorded 4 h (tmax) after oral administration; AUC0-24 was 3.583 mg h/mL and t1/2 was 94.54 h. The study concluded that Rutin of cassava leaves extract, reached maximum concentration within 4 h after oral administration and was inside in the plasma for more than 24 h. Hence, it is recommended to consume cassava leaves extract as herbal medicine, only once a day. Penerbit Universiti Kebangsaan Malaysia 2019-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13893/1/16%20Nugrahaningsih%20WH.pdf Nugrahaningsih, WH and Fatimatuz Zahroh, and Lisdiana, and Ari Yuniastuti, and Rudyatmi, Ely (2019) The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma. Sains Malaysiana, 48 (8). pp. 1707-1712. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The leaves of cassava are used as traditional medicine, to treat ringworm, tumor, abscess, conjunctivitis, sores, headaches, rheumatism and fever diseases in several countries. Phytochemical investigations showed that flavonoids and Rutin constituents of the cassava leaves, berths the need for data as regards safety, effectiveness, toxicity and pharmacokinetics for its usage as herbal medicine. The purpose of this research was to observe pharmacokinetic parameters of Rutin in rat plasma, after oral administration of cassava leaves extract. Pharmacokinetics indicators for absorption was (Cmax, tmax, and AUC0-24h), while elimination was (Ke and t1/2). 14 healthy male Wistar rats were divided into 7 groups (each group with 2 rats), after which a single dose (600 mg) of cassava leaves extract was given orally. Thereafter, blood samples of the wistar rats were collected and separated at different time intervals (0; 0.5; 1; 2; 4; 6; 12; and 24 h). Using HPLC-UV-VIS method, the resulting plasma was analyzed for Rutin concentration. The analysis showed Rutin concentration at 0 mg/mL (0 h), 0.151 mg/mL (0.5 h), 0.176 mg/mL (1 h), 0.18 mg/mL (2 h), 0.184 mg/mL (4 h), 0.163 mg/mL (6 h), 0.15 mg/mL (12 h) and 0.1225 mg/mL (24 h). The main pharmacokinetic parameters were; Cmax 0.184 mg/mL recorded 4 h (tmax) after oral administration; AUC0-24 was 3.583 mg h/mL and t1/2 was 94.54 h. The study concluded that Rutin of cassava leaves extract, reached maximum concentration within 4 h after oral administration and was inside in the plasma for more than 24 h. Hence, it is recommended to consume cassava leaves extract as herbal medicine, only once a day.
format Article
author Nugrahaningsih, WH
Fatimatuz Zahroh,
Lisdiana,
Ari Yuniastuti,
Rudyatmi, Ely
spellingShingle Nugrahaningsih, WH
Fatimatuz Zahroh,
Lisdiana,
Ari Yuniastuti,
Rudyatmi, Ely
The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
author_facet Nugrahaningsih, WH
Fatimatuz Zahroh,
Lisdiana,
Ari Yuniastuti,
Rudyatmi, Ely
author_sort Nugrahaningsih, WH
title The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_short The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_full The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_fullStr The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_full_unstemmed The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_sort effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2019
url http://journalarticle.ukm.my/13893/1/16%20Nugrahaningsih%20WH.pdf
http://journalarticle.ukm.my/13893/
http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
_version_ 1657565435248246784
score 13.211869

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