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Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak)

Mutagenic and antimutagenic activities of lactic acid bacteria (LAB) Lactobacillus plantarum isolated from the local fermented durian (tempoyak) was determined by Ames test (Salmonella/microsome mutagenicity assay). Our study also involved pre-incubation assay against Salmonella typhimurium TA 98 an...

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Main Authors: Asmariah Ahmad,, Safura Salik,, Yap, Wei Boon, Noorhisham Tan Kofli,, Ahmad Rohi Ghazali,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/12936/1/23983-76974-1-PB.pdf
http://journalarticle.ukm.my/12936/
http://ejournal.ukm.my/jskm/issue/view/1072
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spelling my-ukm.journal.129362019-05-17T14:33:36Z http://journalarticle.ukm.my/12936/ Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak) Asmariah Ahmad, Safura Salik, Yap, Wei Boon Noorhisham Tan Kofli, Ahmad Rohi Ghazali, Mutagenic and antimutagenic activities of lactic acid bacteria (LAB) Lactobacillus plantarum isolated from the local fermented durian (tempoyak) was determined by Ames test (Salmonella/microsome mutagenicity assay). Our study also involved pre-incubation assay against Salmonella typhimurium TA 98 and TA 100 bacterial strain in the presence and absence of metabolic activator S9 system. It was found that the L. plantarum showed no mutagenic activity on both S. typhimurium strain TA 98 and TA 100 in the presence and absence of metabolic activator. Significant antimutagenic activity (p < 0.05) was observed in both cell-free supernatant and bacterial cell suspension of L. plantarum as compared to the mutagenicity induced by 2-Aminoanthracene in the presence of metabolic activator. Meanwhile, in the absence of metabolic activator, only the bacterial cells of L. plantarum showed antimutagenicity acitivity against Sodium Azide and 2-Nitrofluorene. In conclusion, L. plantarum could play a vital role as chemopreventive agent by binding to mutagens and suppressing mutagenesis. Thus, L. plantarum could be consider as a good candidate for functional food development as a supplement product to prevent development of colon cancer. Penerbit Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12936/1/23983-76974-1-PB.pdf Asmariah Ahmad, and Safura Salik, and Yap, Wei Boon and Noorhisham Tan Kofli, and Ahmad Rohi Ghazali, (2018) Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak). Jurnal Sains Kesihatan Malaysia, 16 (SI). pp. 23-26. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/1072
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Mutagenic and antimutagenic activities of lactic acid bacteria (LAB) Lactobacillus plantarum isolated from the local fermented durian (tempoyak) was determined by Ames test (Salmonella/microsome mutagenicity assay). Our study also involved pre-incubation assay against Salmonella typhimurium TA 98 and TA 100 bacterial strain in the presence and absence of metabolic activator S9 system. It was found that the L. plantarum showed no mutagenic activity on both S. typhimurium strain TA 98 and TA 100 in the presence and absence of metabolic activator. Significant antimutagenic activity (p < 0.05) was observed in both cell-free supernatant and bacterial cell suspension of L. plantarum as compared to the mutagenicity induced by 2-Aminoanthracene in the presence of metabolic activator. Meanwhile, in the absence of metabolic activator, only the bacterial cells of L. plantarum showed antimutagenicity acitivity against Sodium Azide and 2-Nitrofluorene. In conclusion, L. plantarum could play a vital role as chemopreventive agent by binding to mutagens and suppressing mutagenesis. Thus, L. plantarum could be consider as a good candidate for functional food development as a supplement product to prevent development of colon cancer.
format Article
author Asmariah Ahmad,
Safura Salik,
Yap, Wei Boon
Noorhisham Tan Kofli,
Ahmad Rohi Ghazali,
spellingShingle Asmariah Ahmad,
Safura Salik,
Yap, Wei Boon
Noorhisham Tan Kofli,
Ahmad Rohi Ghazali,
Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak)
author_facet Asmariah Ahmad,
Safura Salik,
Yap, Wei Boon
Noorhisham Tan Kofli,
Ahmad Rohi Ghazali,
author_sort Asmariah Ahmad,
title Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak)
title_short Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak)
title_full Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak)
title_fullStr Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak)
title_full_unstemmed Mutagenicity and antimutagenic activities of lactic acid bacteria (LAB) isolated from fermented durian (tempoyak)
title_sort mutagenicity and antimutagenic activities of lactic acid bacteria (lab) isolated from fermented durian (tempoyak)
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/12936/1/23983-76974-1-PB.pdf
http://journalarticle.ukm.my/12936/
http://ejournal.ukm.my/jskm/issue/view/1072
_version_ 1643738932197720064
score 13.211869

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