Cover Image

Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy

Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered to be an otological emergency. The intratympanic (IT) steroid injection technique is introduced to decrease the side effects of systemic steroids and assumed to deliver a higher concentration of corticosteroids into the affected coc...

Full description

Saved in:
Bibliographic Details
Main Authors: Ho, Hon Lian, Ruszymah Hj. Idrus,, Lokman Saim,, Aminuddin Saim,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/12659/1/20%20Ho%20Hon%20Lian.pdf
http://journalarticle.ukm.my/12659/
http://www.ukm.my/jsm/english_journals/vol47num11_2018/contentsVol47num11_2018.htm
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-ukm.journal.12659
record_format eprints
spelling my-ukm.journal.126592019-03-17T11:22:44Z http://journalarticle.ukm.my/12659/ Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy Ho, Hon Lian Ruszymah Hj. Idrus, Lokman Saim, Aminuddin Saim, Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered to be an otological emergency. The intratympanic (IT) steroid injection technique is introduced to decrease the side effects of systemic steroids and assumed to deliver a higher concentration of corticosteroids into the affected cochlea. The objective of the current study was to evaluate the hearing outcomes of high dose IT methylprednisolone among ISSNHL patients after failure of systemic corticosteroid therapy (SCT). Hearing outcomes of SCT were evaluated over a 15 months period. Upon failure of SCT, the treatment was continued with higher dose IT steroid (methylprednisolone 62.5 mg/mL). Pre-treatment and post-treatment audiometric evaluations were analysed using pure tone audiogram (PTA). There were 36 patients diagnosed with ISSNHL included in the study. After two weeks of SCT, eighteen (56.3%) patients had hearing improvement of more than 10 dB. Another fourteen (43.7%) patients had no hearing improvement (less than 10 dB). Following that, twelve patients were recruited for weekly IT methylprednisolone for three weeks. During the one month follow up after completion of IT therapy, six patients (50%) showed more than 10 dB improvement in the PTA with a mean of 19.37 dB (p<0.05). Out of the six, two patients had more than 20 dB hearing improvement. Almost all patients in this study had an improvement in their symptoms of tinnitus and vertigo. High dose IT methylprednisolone after failure of SCT resulted in significant improvement in the patients’ hearing outcome during one month follow up. The IT therapy not only improved the patients’ hearing but in addition reduced the symptoms of tinnitus and vertigo. Penerbit Universiti Kebangsaan Malaysia 2018-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12659/1/20%20Ho%20Hon%20Lian.pdf Ho, Hon Lian and Ruszymah Hj. Idrus, and Lokman Saim, and Aminuddin Saim, (2018) Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy. Sains Malaysiana, 47 (11). pp. 2777-2782. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num11_2018/contentsVol47num11_2018.htm
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered to be an otological emergency. The intratympanic (IT) steroid injection technique is introduced to decrease the side effects of systemic steroids and assumed to deliver a higher concentration of corticosteroids into the affected cochlea. The objective of the current study was to evaluate the hearing outcomes of high dose IT methylprednisolone among ISSNHL patients after failure of systemic corticosteroid therapy (SCT). Hearing outcomes of SCT were evaluated over a 15 months period. Upon failure of SCT, the treatment was continued with higher dose IT steroid (methylprednisolone 62.5 mg/mL). Pre-treatment and post-treatment audiometric evaluations were analysed using pure tone audiogram (PTA). There were 36 patients diagnosed with ISSNHL included in the study. After two weeks of SCT, eighteen (56.3%) patients had hearing improvement of more than 10 dB. Another fourteen (43.7%) patients had no hearing improvement (less than 10 dB). Following that, twelve patients were recruited for weekly IT methylprednisolone for three weeks. During the one month follow up after completion of IT therapy, six patients (50%) showed more than 10 dB improvement in the PTA with a mean of 19.37 dB (p<0.05). Out of the six, two patients had more than 20 dB hearing improvement. Almost all patients in this study had an improvement in their symptoms of tinnitus and vertigo. High dose IT methylprednisolone after failure of SCT resulted in significant improvement in the patients’ hearing outcome during one month follow up. The IT therapy not only improved the patients’ hearing but in addition reduced the symptoms of tinnitus and vertigo.
format Article
author Ho, Hon Lian
Ruszymah Hj. Idrus,
Lokman Saim,
Aminuddin Saim,
spellingShingle Ho, Hon Lian
Ruszymah Hj. Idrus,
Lokman Saim,
Aminuddin Saim,
Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
author_facet Ho, Hon Lian
Ruszymah Hj. Idrus,
Lokman Saim,
Aminuddin Saim,
author_sort Ho, Hon Lian
title Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_short Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_full Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_fullStr Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_full_unstemmed Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_sort intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/12659/1/20%20Ho%20Hon%20Lian.pdf
http://journalarticle.ukm.my/12659/
http://www.ukm.my/jsm/english_journals/vol47num11_2018/contentsVol47num11_2018.htm
_version_ 1643738852016259072
score 13.211869

Similar Items