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Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering

Composite fabricated from the combination of biodegradable polymer and bioactive filler is beneficial for bone tissue engineering if the biomaterial can perform similar characteristics of the natural inorganic-organic structures of bone. In this study, we have investigated the thermoplastic starch (...

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Main Authors: Syed Nuzul Fadzli Syed Adam,, Azlin Fazlina Osman,, Roslinda Shamsudin,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/12136/1/27%20Syed%20Nuzul%20Fadzli%20Syed%20Adam.pdf
http://journalarticle.ukm.my/12136/
http://www.ukm.my/jsm/english_journals/vol47num6_2018/contentsVol47num6_2018.html
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spelling my-ukm.journal.121362018-09-28T22:46:29Z http://journalarticle.ukm.my/12136/ Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering Syed Nuzul Fadzli Syed Adam, Azlin Fazlina Osman, Roslinda Shamsudin, Composite fabricated from the combination of biodegradable polymer and bioactive filler is beneficial for bone tissue engineering if the biomaterial can perform similar characteristics of the natural inorganic-organic structures of bone. In this study, we have investigated the thermoplastic starch (TPS)/sol-gel derived bioglass composite as new biomaterial for bone tissue engineering. The composites were produced using selected TPS/bioglass mass ratio of 100/0, 95/5, 90/10, 85/15 and 80/20 by a combination of solvent casting and salt leaching techniques. Tensile test results showed the addition of bioglass increased the tensile strength and Young’s modulus, but reduced the elongation at break of the samples. The modulus of all samples were higher than the requirement for cancellous bone (10-20 MPa). The SEM imaging showed the presence of porous structure on the surface of all samples. XRD results confirmed the formation of hydroxycarbonate apatite (HCA) layer on the surface of bioglass containing samples; indicating the occurrence of surface reactions when the samples were immersed in Simulated Body Fluid (SBF). Furthermore, the presence of P-O stretch band in FTIR spectrum between 1000 and 1150 cm-1 and Si-O-Si stretch band at 1000 cm-1 also proved the bioactivity of TPS/bioglass composite. The in vitro biodegradability analysis shows the biodegradability of TPS/bioglass composite decreases with increasing mass ratio of the bioglass. Penerbit Universiti Kebangsaan Malaysia 2018-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12136/1/27%20Syed%20Nuzul%20Fadzli%20Syed%20Adam.pdf Syed Nuzul Fadzli Syed Adam, and Azlin Fazlina Osman, and Roslinda Shamsudin, (2018) Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering. Sains Malaysiana, 47 (6). pp. 1303-1310. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num6_2018/contentsVol47num6_2018.html
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Composite fabricated from the combination of biodegradable polymer and bioactive filler is beneficial for bone tissue engineering if the biomaterial can perform similar characteristics of the natural inorganic-organic structures of bone. In this study, we have investigated the thermoplastic starch (TPS)/sol-gel derived bioglass composite as new biomaterial for bone tissue engineering. The composites were produced using selected TPS/bioglass mass ratio of 100/0, 95/5, 90/10, 85/15 and 80/20 by a combination of solvent casting and salt leaching techniques. Tensile test results showed the addition of bioglass increased the tensile strength and Young’s modulus, but reduced the elongation at break of the samples. The modulus of all samples were higher than the requirement for cancellous bone (10-20 MPa). The SEM imaging showed the presence of porous structure on the surface of all samples. XRD results confirmed the formation of hydroxycarbonate apatite (HCA) layer on the surface of bioglass containing samples; indicating the occurrence of surface reactions when the samples were immersed in Simulated Body Fluid (SBF). Furthermore, the presence of P-O stretch band in FTIR spectrum between 1000 and 1150 cm-1 and Si-O-Si stretch band at 1000 cm-1 also proved the bioactivity of TPS/bioglass composite. The in vitro biodegradability analysis shows the biodegradability of TPS/bioglass composite decreases with increasing mass ratio of the bioglass.
format Article
author Syed Nuzul Fadzli Syed Adam,
Azlin Fazlina Osman,
Roslinda Shamsudin,
spellingShingle Syed Nuzul Fadzli Syed Adam,
Azlin Fazlina Osman,
Roslinda Shamsudin,
Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering
author_facet Syed Nuzul Fadzli Syed Adam,
Azlin Fazlina Osman,
Roslinda Shamsudin,
author_sort Syed Nuzul Fadzli Syed Adam,
title Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering
title_short Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering
title_full Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering
title_fullStr Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering
title_full_unstemmed Tensile properties, biodegradability and bioactivity of thermoplastic starch (TPS)/bioglass composites for bone tissue engineering
title_sort tensile properties, biodegradability and bioactivity of thermoplastic starch (tps)/bioglass composites for bone tissue engineering
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/12136/1/27%20Syed%20Nuzul%20Fadzli%20Syed%20Adam.pdf
http://journalarticle.ukm.my/12136/
http://www.ukm.my/jsm/english_journals/vol47num6_2018/contentsVol47num6_2018.html
_version_ 1643738703359639552
score 13.211869

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