Cover Image

Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution

Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternativ...

Full description

Saved in:
Bibliographic Details
Main Authors: Thirunanthini Manoharan,, Jayanthi Arasan,, Habshah Midi,, Mohd Bakri Adam,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:http://journalarticle.ukm.my/11723/1/31%20Thirunanthini.pdf
http://journalarticle.ukm.my/11723/
http://www.ukm.my/jsm/english_journals/vol46num12_2017/contentsVol46num12_2017.htm
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-ukm.journal.11723
record_format eprints
spelling my-ukm.journal.117232018-05-30T00:02:33Z http://journalarticle.ukm.my/11723/ Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam, Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternative inferential procedures that ease the assumptions of normality and unconventionally relies on the distribution of data in hand. In this research, a three parameter log-normal parametric survival model was extended to incorporate left-truncated and right censored medical data with covariates. Following that, bootstrap inferential procedures using non-parametric and parametric bootstrap samples were applied to the parameters of this model. The performance of the parameter estimates was assessed at various combinations of truncation and censoring levels via a simulation study. The recommended bootstrap intervals were applied to a lung cancer survival data. Penerbit Universiti Kebangsaan Malaysia 2017-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11723/1/31%20Thirunanthini.pdf Thirunanthini Manoharan, and Jayanthi Arasan, and Habshah Midi, and Mohd Bakri Adam, (2017) Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution. Sains Malaysiana, 46 (12). pp. 2529-2539. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num12_2017/contentsVol46num12_2017.htm
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternative inferential procedures that ease the assumptions of normality and unconventionally relies on the distribution of data in hand. In this research, a three parameter log-normal parametric survival model was extended to incorporate left-truncated and right censored medical data with covariates. Following that, bootstrap inferential procedures using non-parametric and parametric bootstrap samples were applied to the parameters of this model. The performance of the parameter estimates was assessed at various combinations of truncation and censoring levels via a simulation study. The recommended bootstrap intervals were applied to a lung cancer survival data.
format Article
author Thirunanthini Manoharan,
Jayanthi Arasan,
Habshah Midi,
Mohd Bakri Adam,
spellingShingle Thirunanthini Manoharan,
Jayanthi Arasan,
Habshah Midi,
Mohd Bakri Adam,
Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
author_facet Thirunanthini Manoharan,
Jayanthi Arasan,
Habshah Midi,
Mohd Bakri Adam,
author_sort Thirunanthini Manoharan,
title Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_short Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_full Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_fullStr Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_full_unstemmed Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_sort bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2017
url http://journalarticle.ukm.my/11723/1/31%20Thirunanthini.pdf
http://journalarticle.ukm.my/11723/
http://www.ukm.my/jsm/english_journals/vol46num12_2017/contentsVol46num12_2017.htm
_version_ 1643738582653861888
score 13.211869

Similar Items