Cover Image

Screening and evaluation of antioxidant activities of selected naphthalene compounds

The antioxidant activities of twelve naphthalene compounds containing (E)-1-((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1-((3-bromophenylimino) methyl) naphthalen-2-ol (NAPH2), E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl) naphthalen-2-ol, (E)-1-((4-bromo-2-(trifluoromethoxy)...

Full description

Saved in:
Bibliographic Details
Main Authors: Ozen, Tevfik, Macit, Mustafa, Toka, Mehmet
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/11498/1/16548-69330-1-PB.pdf
http://journalarticle.ukm.my/11498/
http://ejournal.ukm.my/jskm/issue/view/684
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-ukm.journal.11498
record_format eprints
spelling my-ukm.journal.114982018-04-02T02:55:56Z http://journalarticle.ukm.my/11498/ Screening and evaluation of antioxidant activities of selected naphthalene compounds Ozen, Tevfik Macit, Mustafa Toka, Mehmet The antioxidant activities of twelve naphthalene compounds containing (E)-1-((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1-((3-bromophenylimino) methyl) naphthalen-2-ol (NAPH2), E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl) naphthalen-2-ol, (E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl)naphthalen-2-ol (NAPH3), (E)-1-((2-methoxy-5-(trifluoromethyl) phenylimino) methyl) naphthalen-2-ol (NAPH4), (E)-1-((naphthalen-2-ylimino) methyl) naphthalen-2-ol (NAPH5), (E)-1-((2-bromo-3-methylphenylimino) methyl) naphthalen-2-ol (NAPH6), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-3-methylaniline (NAPH7), (E)-4-ethoxy-N-((2-ethoxynaphthalen-1-yl) methylene) aniline (NAPH8), (E)-N-((2-ethoxynaphthalen-1-yl) methylene) naphthalen-1-amine (NAPH9), (E)-1-(2,5-difluorophenyl)-N-((2-ethoxynaphthalen-1-yl) methylene) methanamine (NAPH10), (E)-N-((2-ethoxynaphthalen-1-yl) methylene)-4-fluoroaniline (NAPH11), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-2-ethylaniline (NAPH12) were investigated in vitro by antioxidant activity (phosphomolybdenum assay), reducing power, H2O2 scavenging activity, metal chelating effects and lipid peroxidation. Scavenging activities of the naphthalen compounds were tested against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals. Most of them are potent antioxidant, radical superoxide anion scavengers and in vitro inhibition of lipid peroxidation. The compounds; NAPH5, NAPH10 and NAPH12 were found to exhibit promising antioxidant profiles at 10 and 50 mM concentrations. Among these, NAPH5 at higher concentration was the most active compound in inhibiting lipid peroxidation as shown in the homogenates of kidney, heart and spleen. The presented results validate that NAPH5, NAPH10 and NAPH12 can be possessed as a source of antioxidant potential and a rich source of synthetic antioxidant for medicinal or foods. Penerbit Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11498/1/16548-69330-1-PB.pdf Ozen, Tevfik and Macit, Mustafa and Toka, Mehmet (2018) Screening and evaluation of antioxidant activities of selected naphthalene compounds. Jurnal Sains Kesihatan Malaysia, 16 (1). pp. 45-55. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/684
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The antioxidant activities of twelve naphthalene compounds containing (E)-1-((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1-((3-bromophenylimino) methyl) naphthalen-2-ol (NAPH2), E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl) naphthalen-2-ol, (E)-1-((4-bromo-2-(trifluoromethoxy) phenylimino) methyl)naphthalen-2-ol (NAPH3), (E)-1-((2-methoxy-5-(trifluoromethyl) phenylimino) methyl) naphthalen-2-ol (NAPH4), (E)-1-((naphthalen-2-ylimino) methyl) naphthalen-2-ol (NAPH5), (E)-1-((2-bromo-3-methylphenylimino) methyl) naphthalen-2-ol (NAPH6), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-3-methylaniline (NAPH7), (E)-4-ethoxy-N-((2-ethoxynaphthalen-1-yl) methylene) aniline (NAPH8), (E)-N-((2-ethoxynaphthalen-1-yl) methylene) naphthalen-1-amine (NAPH9), (E)-1-(2,5-difluorophenyl)-N-((2-ethoxynaphthalen-1-yl) methylene) methanamine (NAPH10), (E)-N-((2-ethoxynaphthalen-1-yl) methylene)-4-fluoroaniline (NAPH11), (E)-N-((2-ethoxynaphthalen-1-yl)methylene)-2-ethylaniline (NAPH12) were investigated in vitro by antioxidant activity (phosphomolybdenum assay), reducing power, H2O2 scavenging activity, metal chelating effects and lipid peroxidation. Scavenging activities of the naphthalen compounds were tested against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals. Most of them are potent antioxidant, radical superoxide anion scavengers and in vitro inhibition of lipid peroxidation. The compounds; NAPH5, NAPH10 and NAPH12 were found to exhibit promising antioxidant profiles at 10 and 50 mM concentrations. Among these, NAPH5 at higher concentration was the most active compound in inhibiting lipid peroxidation as shown in the homogenates of kidney, heart and spleen. The presented results validate that NAPH5, NAPH10 and NAPH12 can be possessed as a source of antioxidant potential and a rich source of synthetic antioxidant for medicinal or foods.
format Article
author Ozen, Tevfik
Macit, Mustafa
Toka, Mehmet
spellingShingle Ozen, Tevfik
Macit, Mustafa
Toka, Mehmet
Screening and evaluation of antioxidant activities of selected naphthalene compounds
author_facet Ozen, Tevfik
Macit, Mustafa
Toka, Mehmet
author_sort Ozen, Tevfik
title Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_short Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_full Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_fullStr Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_full_unstemmed Screening and evaluation of antioxidant activities of selected naphthalene compounds
title_sort screening and evaluation of antioxidant activities of selected naphthalene compounds
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/11498/1/16548-69330-1-PB.pdf
http://journalarticle.ukm.my/11498/
http://ejournal.ukm.my/jskm/issue/view/684
_version_ 1643738519293657088
score 13.211869

Similar Items