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Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients

The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI...

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Main Authors: Nurul Hanim Nasaruddin,, Ahmad Nazlim Yusoff,, Sharanjeet Kaur,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf
http://journalarticle.ukm.my/11455/
http://ejournal.ukm.my/jskm/issue/view/635
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spelling my-ukm.journal.114552018-03-16T01:05:58Z http://journalarticle.ukm.my/11455/ Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients Nurul Hanim Nasaruddin, Ahmad Nazlim Yusoff, Sharanjeet Kaur, The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD. Penerbit Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf Nurul Hanim Nasaruddin, and Ahmad Nazlim Yusoff, and Sharanjeet Kaur, (2017) Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients. Jurnal Sains Kesihatan Malaysia, 15 (1). pp. 27-32. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/635
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Automated Perimetry (SAP) and functional Magnetic Resonance Imaging (fMRI) respectively. The fMRI scans and SAP test were both carried out in Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Two types of black-and-white checkerboard pattern were displayed to the participants during the fMRI scans. The fMRI data were analyzed using WFU pickatlas toolbox targeting visual cortex area. The results showed that there was no significant difference in number of activated voxel between the three groups in visual cortex (BA 17, 18 and 19) while viewing all the given stimuli (p > 0.05). The pattern standard deviation (PSD) of SAP for visual field also revealed no significant differences (p > 0.05) in all groups of participants. However, negative correlation between PSD and fMRI activation was observed. The PSD values increased with a decrease in fMRI activation. With reference to visual field analysis, the results suggest that glaucomatous neuropathy of POAG patients has led to a gradual decrease in visual cortex activation and a gradual increase in PSD.
format Article
author Nurul Hanim Nasaruddin,
Ahmad Nazlim Yusoff,
Sharanjeet Kaur,
spellingShingle Nurul Hanim Nasaruddin,
Ahmad Nazlim Yusoff,
Sharanjeet Kaur,
Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
author_facet Nurul Hanim Nasaruddin,
Ahmad Nazlim Yusoff,
Sharanjeet Kaur,
author_sort Nurul Hanim Nasaruddin,
title Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_short Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_full Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_fullStr Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_full_unstemmed Functional MRI characteristics in visual cortex (BA 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) patients
title_sort functional mri characteristics in visual cortex (ba 17, 18 and 19) corresponding to the visual field of normal, glaucoma suspect (gs) and primary open angle glaucoma (poag) patients
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2017
url http://journalarticle.ukm.my/11455/1/16741-47126-1-SM.pdf
http://journalarticle.ukm.my/11455/
http://ejournal.ukm.my/jskm/issue/view/635
_version_ 1643738500474863616
score 13.211869

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