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Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis

Micro computed tomography (micro-CT) imaging is a useful tool to monitor fracture healing in osteoporosis model. It creates a 3-D image of the fracture callus which can be analysed to assess bone parameters quantitatively. In this study, micro-CT was used to assess the fracture healing of orchidecto...

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Main Authors: Azri J,, Ahmad Nazrun Shuid,, Sabarul Afian Mokhtar,, Mohd Fadli K,, Norliza Muhammad,
Format: Article
Language:English
Published: Faculty of Medicine, Universiti Kebangsaan Malaysia 2016
Online Access:http://journalarticle.ukm.my/10849/1/15_azri_et_al_pdf_85064.pdf
http://journalarticle.ukm.my/10849/
http://www.medicineandhealthukm.com/toc/11/2
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spelling my-ukm.journal.108492017-10-12T09:36:50Z http://journalarticle.ukm.my/10849/ Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis Azri J, Ahmad Nazrun Shuid, Sabarul Afian Mokhtar, Mohd Fadli K, Norliza Muhammad, Micro computed tomography (micro-CT) imaging is a useful tool to monitor fracture healing in osteoporosis model. It creates a 3-D image of the fracture callus which can be analysed to assess bone parameters quantitatively. In this study, micro-CT was used to assess the fracture healing of orchidectomised rats, an androgen-deficient osteoporosis model. The effects of Eurycoma longifolia, a medicinal plant with pro-androgenic effects, on fracture healing were assessed. The rats were grouped into orchidectomised-control (ORX), sham-operated (SHAM), orchidectomised and injected with testosterone intramuscularly once weekly (TEN) and orchidectomised and daily oral gavage of Eurycoma longifolia (EL). Treatment duration was six weeks following bone fracture. Fracture was induced in the right tibia of all the rats. A total of 100 axial slices above and below fracture line were scanned with a micro-CT. The micro-CT analysis was able to detect significant difference in the fracture healing rate of ORX and TEN groups. The bridging cortices and fraction of mineralized tissue of the bridging cortices of the callous of ORX group was significantly lower than TEN group. No significant micro-CT changes were seen in the fracture healing of the EL group. The effect of EL on fracture healing was not demonstrable in orchidectomised rat model. Faculty of Medicine, Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10849/1/15_azri_et_al_pdf_85064.pdf Azri J, and Ahmad Nazrun Shuid, and Sabarul Afian Mokhtar, and Mohd Fadli K, and Norliza Muhammad, (2016) Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis. Medicine & Health, 11 (2). pp. 267-277. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc/11/2
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Micro computed tomography (micro-CT) imaging is a useful tool to monitor fracture healing in osteoporosis model. It creates a 3-D image of the fracture callus which can be analysed to assess bone parameters quantitatively. In this study, micro-CT was used to assess the fracture healing of orchidectomised rats, an androgen-deficient osteoporosis model. The effects of Eurycoma longifolia, a medicinal plant with pro-androgenic effects, on fracture healing were assessed. The rats were grouped into orchidectomised-control (ORX), sham-operated (SHAM), orchidectomised and injected with testosterone intramuscularly once weekly (TEN) and orchidectomised and daily oral gavage of Eurycoma longifolia (EL). Treatment duration was six weeks following bone fracture. Fracture was induced in the right tibia of all the rats. A total of 100 axial slices above and below fracture line were scanned with a micro-CT. The micro-CT analysis was able to detect significant difference in the fracture healing rate of ORX and TEN groups. The bridging cortices and fraction of mineralized tissue of the bridging cortices of the callous of ORX group was significantly lower than TEN group. No significant micro-CT changes were seen in the fracture healing of the EL group. The effect of EL on fracture healing was not demonstrable in orchidectomised rat model.
format Article
author Azri J,
Ahmad Nazrun Shuid,
Sabarul Afian Mokhtar,
Mohd Fadli K,
Norliza Muhammad,
spellingShingle Azri J,
Ahmad Nazrun Shuid,
Sabarul Afian Mokhtar,
Mohd Fadli K,
Norliza Muhammad,
Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis
author_facet Azri J,
Ahmad Nazrun Shuid,
Sabarul Afian Mokhtar,
Mohd Fadli K,
Norliza Muhammad,
author_sort Azri J,
title Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis
title_short Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis
title_full Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis
title_fullStr Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis
title_full_unstemmed Effects of Eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis
title_sort effects of eurycoma longifolia on fracture healing of androgen-deficient osteoporosis model: a micro computed tomograph analysis
publisher Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate 2016
url http://journalarticle.ukm.my/10849/1/15_azri_et_al_pdf_85064.pdf
http://journalarticle.ukm.my/10849/
http://www.medicineandhealthukm.com/toc/11/2
_version_ 1643738279586037760
score 13.211869

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