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Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet

Menopause, a cessation of menstrual bleeding, is directly related to serious illness confined to cardiovascular disease (CVD) such as hypertension and stroke. The oestrogen withdrawal and consumption of high cholesterol diet has a detrimental effect on cardiovascular function and metabolism in menop...

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Main Authors: Kumeshini S,, Nurshazana A,, Faizah Othman,, Kamsiah Jaarin,, Srijit Dass,, Zar, Chi Thent
Format: Article
Language:English
Published: Faculty of Medicine, Universiti Kebangsaan Malaysia 2016
Online Access:http://journalarticle.ukm.my/10840/1/6_kumeshini_et_al_pdf_15539.pdf
http://journalarticle.ukm.my/10840/
http://www.medicineandhealthukm.com/toc/11/2
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spelling my-ukm.journal.108402017-10-12T09:21:23Z http://journalarticle.ukm.my/10840/ Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet Kumeshini S, Nurshazana A, Faizah Othman, Kamsiah Jaarin, Srijit Dass, Zar, Chi Thent Menopause, a cessation of menstrual bleeding, is directly related to serious illness confined to cardiovascular disease (CVD) such as hypertension and stroke. The oestrogen withdrawal and consumption of high cholesterol diet has a detrimental effect on cardiovascular function and metabolism in menopausal women. The present study was aimed to develop the hypertensive rat model in the ovariectomised Sprague Dawley rats fed with 2% cholesterol diet following a short term period. Eighteen Sprague-Dawley rats were randomly divided into three groups; Sham control (sham), ovariectomized control fed with normal diet (Ovx +N), ovariectomized rats fed with 2% cholesterol diet (Ovx + Cho) for four weeks. At the end of the study, the food intake and body weight were measured. The systolic, diastolic and mean blood pressure was determined. OVX+Cho showed significant increase in physiological changes such as body weight and food intake compared to Ovx+N group. The significant increase in systolic, diastolic and mean blood pressure was observed in Ovx+Cho group. Based on the above findings, it is believed that feeding cholesterol diet for four weeks (short term) results in significant increase in the blood pressure, food intake and body weight in the ovariectomised rats. Faculty of Medicine, Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10840/1/6_kumeshini_et_al_pdf_15539.pdf Kumeshini S, and Nurshazana A, and Faizah Othman, and Kamsiah Jaarin, and Srijit Dass, and Zar, Chi Thent (2016) Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet. Medicine & Health, 11 (2). pp. 171-180. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc/11/2
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Menopause, a cessation of menstrual bleeding, is directly related to serious illness confined to cardiovascular disease (CVD) such as hypertension and stroke. The oestrogen withdrawal and consumption of high cholesterol diet has a detrimental effect on cardiovascular function and metabolism in menopausal women. The present study was aimed to develop the hypertensive rat model in the ovariectomised Sprague Dawley rats fed with 2% cholesterol diet following a short term period. Eighteen Sprague-Dawley rats were randomly divided into three groups; Sham control (sham), ovariectomized control fed with normal diet (Ovx +N), ovariectomized rats fed with 2% cholesterol diet (Ovx + Cho) for four weeks. At the end of the study, the food intake and body weight were measured. The systolic, diastolic and mean blood pressure was determined. OVX+Cho showed significant increase in physiological changes such as body weight and food intake compared to Ovx+N group. The significant increase in systolic, diastolic and mean blood pressure was observed in Ovx+Cho group. Based on the above findings, it is believed that feeding cholesterol diet for four weeks (short term) results in significant increase in the blood pressure, food intake and body weight in the ovariectomised rats.
format Article
author Kumeshini S,
Nurshazana A,
Faizah Othman,
Kamsiah Jaarin,
Srijit Dass,
Zar, Chi Thent
spellingShingle Kumeshini S,
Nurshazana A,
Faizah Othman,
Kamsiah Jaarin,
Srijit Dass,
Zar, Chi Thent
Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
author_facet Kumeshini S,
Nurshazana A,
Faizah Othman,
Kamsiah Jaarin,
Srijit Dass,
Zar, Chi Thent
author_sort Kumeshini S,
title Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_short Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_full Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_fullStr Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_full_unstemmed Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_sort development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
publisher Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate 2016
url http://journalarticle.ukm.my/10840/1/6_kumeshini_et_al_pdf_15539.pdf
http://journalarticle.ukm.my/10840/
http://www.medicineandhealthukm.com/toc/11/2
_version_ 1643738276442406912
score 13.211869

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