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Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract

Polygonum minus is a plant rich in flavonoids and antioxidants beneficial for reducing oxidative stress and lipid peroxidation in neuronal membranes. This randomized, double-blind, placebo-controlled study evaluated the potential benefits of P. minus extract (LineMinusTM) towards improving cognitive...

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Main Authors: Hanis Mastura Yahya,, Suzana Shahar,, Siti Nur Arina Ismail,, Ainor Farahin Aziz,, Normah Che Din,, Bibi Nabihah Abdul Hakim,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:http://journalarticle.ukm.my/10677/1/09%20Hanis%20Mastura.pdf
http://journalarticle.ukm.my/10677/
http://www.ukm.my/jsm/english_journals/vol46num2_2017/contentsVol46num2_2017.html
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spelling my-ukm.journal.106772017-09-20T09:09:54Z http://journalarticle.ukm.my/10677/ Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract Hanis Mastura Yahya, Suzana Shahar, Siti Nur Arina Ismail, Ainor Farahin Aziz, Normah Che Din, Bibi Nabihah Abdul Hakim, Polygonum minus is a plant rich in flavonoids and antioxidants beneficial for reducing oxidative stress and lipid peroxidation in neuronal membranes. This randomized, double-blind, placebo-controlled study evaluated the potential benefits of P. minus extract (LineMinusTM) towards improving cognitive function, mood status and quality of life. Thirty five middle-aged women (35-55 years old) were randomized into intervention (n=17) and control group (n=18). Two capsules of P. minus (250 mg) or placebo (100 mg maltodextrin) each were taken once daily for six weeks. Cognitive tests, mood and anthropometric measurements were measured at baseline, week 3 and week 6, whilst biomarkers were measured at baseline and week 6. Parameters related to mood and quality of life including energy/fatigue, social functioning and general health significantly improved from baseline to week 6 in the intervention group (p<0.05). Mean score for cognitive tests (i.e. digit span, comprehensive trail making test (CTMT) and three domains of CNS vital sign (CNSVS)] improved significantly in both intervention and control groups (p<0.05). There was a significant decrease of mean uric acid, estimated glomerular filtration rate (eGFR), total cholesterol and glycated hemoglobin (HbA1C) in the intervention group from baseline to week 6. P. minus supplementation has the potential to improve mood and quality of life and no adverse effects were reported by the participants after 6 weeks supplementation. Penerbit Universiti Kebangsaan Malaysia 2017-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10677/1/09%20Hanis%20Mastura.pdf Hanis Mastura Yahya, and Suzana Shahar, and Siti Nur Arina Ismail, and Ainor Farahin Aziz, and Normah Che Din, and Bibi Nabihah Abdul Hakim, (2017) Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract. Sains Malaysiana, 46 (2). pp. 245-254. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num2_2017/contentsVol46num2_2017.html
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Polygonum minus is a plant rich in flavonoids and antioxidants beneficial for reducing oxidative stress and lipid peroxidation in neuronal membranes. This randomized, double-blind, placebo-controlled study evaluated the potential benefits of P. minus extract (LineMinusTM) towards improving cognitive function, mood status and quality of life. Thirty five middle-aged women (35-55 years old) were randomized into intervention (n=17) and control group (n=18). Two capsules of P. minus (250 mg) or placebo (100 mg maltodextrin) each were taken once daily for six weeks. Cognitive tests, mood and anthropometric measurements were measured at baseline, week 3 and week 6, whilst biomarkers were measured at baseline and week 6. Parameters related to mood and quality of life including energy/fatigue, social functioning and general health significantly improved from baseline to week 6 in the intervention group (p<0.05). Mean score for cognitive tests (i.e. digit span, comprehensive trail making test (CTMT) and three domains of CNS vital sign (CNSVS)] improved significantly in both intervention and control groups (p<0.05). There was a significant decrease of mean uric acid, estimated glomerular filtration rate (eGFR), total cholesterol and glycated hemoglobin (HbA1C) in the intervention group from baseline to week 6. P. minus supplementation has the potential to improve mood and quality of life and no adverse effects were reported by the participants after 6 weeks supplementation.
format Article
author Hanis Mastura Yahya,
Suzana Shahar,
Siti Nur Arina Ismail,
Ainor Farahin Aziz,
Normah Che Din,
Bibi Nabihah Abdul Hakim,
spellingShingle Hanis Mastura Yahya,
Suzana Shahar,
Siti Nur Arina Ismail,
Ainor Farahin Aziz,
Normah Che Din,
Bibi Nabihah Abdul Hakim,
Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract
author_facet Hanis Mastura Yahya,
Suzana Shahar,
Siti Nur Arina Ismail,
Ainor Farahin Aziz,
Normah Che Din,
Bibi Nabihah Abdul Hakim,
author_sort Hanis Mastura Yahya,
title Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract
title_short Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract
title_full Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract
title_fullStr Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract
title_full_unstemmed Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract
title_sort mood, cognitive function and quality of life improvements in middle aged women following supplementation with polygonum minus extract
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2017
url http://journalarticle.ukm.my/10677/1/09%20Hanis%20Mastura.pdf
http://journalarticle.ukm.my/10677/
http://www.ukm.my/jsm/english_journals/vol46num2_2017/contentsVol46num2_2017.html
_version_ 1643738216019263488
score 13.223943

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