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The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats

This study examines the effect of Cosmos caudatus on plasma corticosterone levels following a chronic repetitive forced swimming stress (FSS). Male Sprague-Dawley strains of rats weighing 90–120 g were used. The first group was the control, administered only with saline solution. Second and third...

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Main Authors: Mohd Hadzrul Hisham A.M.,, Osman C.B.,, Ainsah O.,, Rohaya A.,, Aishah A.,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2015
Online Access:http://journalarticle.ukm.my/10355/1/44_1_21.pdf
http://journalarticle.ukm.my/10355/
http://www.mabjournal.com/index.php?option=com_content&view=article&id=520&catid=59:current-view&Itemid=56
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spelling my-ukm.journal.103552017-04-21T09:34:35Z http://journalarticle.ukm.my/10355/ The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats Mohd Hadzrul Hisham A.M., Osman C.B., Ainsah O., Rohaya A., Aishah A., This study examines the effect of Cosmos caudatus on plasma corticosterone levels following a chronic repetitive forced swimming stress (FSS). Male Sprague-Dawley strains of rats weighing 90–120 g were used. The first group was the control, administered only with saline solution. Second and third groups received quercetin (100mg/kg and 200mg/kg) respectively, while the fourth and fifth groups were treated with C. caudatus’s extract (100mg/kg and 200mg/kg) respectively. The rats were subjected to FSS for 15 minutes daily. The tests revealed a significant reduction in plasma corticosterone level in all treated groups (except the second group) compared to the control. At the end of the experiment, the third, fourth and fifth groups had a reduction in plasma corticosterone level which were 153.950 nmol/l ± 2.98, 145.262 nmol/l ± 2.04, 134.488 nmol/l ± 2.70, respectively. The group treated with 200mg/kg of C. caudatus was most significant in reducing plasma corticosterone (p< 0.005). The present study suggests the ability of C. caudatus to reduce the plasma corticosterone level. Penerbit Universiti Kebangsaan Malaysia 2015-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10355/1/44_1_21.pdf Mohd Hadzrul Hisham A.M., and Osman C.B., and Ainsah O., and Rohaya A., and Aishah A., (2015) The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats. Malaysian Applied Biology, 44 (3). pp. 121-125. ISSN 0126-8643 http://www.mabjournal.com/index.php?option=com_content&view=article&id=520&catid=59:current-view&Itemid=56
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description This study examines the effect of Cosmos caudatus on plasma corticosterone levels following a chronic repetitive forced swimming stress (FSS). Male Sprague-Dawley strains of rats weighing 90–120 g were used. The first group was the control, administered only with saline solution. Second and third groups received quercetin (100mg/kg and 200mg/kg) respectively, while the fourth and fifth groups were treated with C. caudatus’s extract (100mg/kg and 200mg/kg) respectively. The rats were subjected to FSS for 15 minutes daily. The tests revealed a significant reduction in plasma corticosterone level in all treated groups (except the second group) compared to the control. At the end of the experiment, the third, fourth and fifth groups had a reduction in plasma corticosterone level which were 153.950 nmol/l ± 2.98, 145.262 nmol/l ± 2.04, 134.488 nmol/l ± 2.70, respectively. The group treated with 200mg/kg of C. caudatus was most significant in reducing plasma corticosterone (p< 0.005). The present study suggests the ability of C. caudatus to reduce the plasma corticosterone level.
format Article
author Mohd Hadzrul Hisham A.M.,
Osman C.B.,
Ainsah O.,
Rohaya A.,
Aishah A.,
spellingShingle Mohd Hadzrul Hisham A.M.,
Osman C.B.,
Ainsah O.,
Rohaya A.,
Aishah A.,
The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats
author_facet Mohd Hadzrul Hisham A.M.,
Osman C.B.,
Ainsah O.,
Rohaya A.,
Aishah A.,
author_sort Mohd Hadzrul Hisham A.M.,
title The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats
title_short The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats
title_full The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats
title_fullStr The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats
title_full_unstemmed The effect of Cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats
title_sort effect of cosmos caudatus on plasma corticosterone level following a chronic repetitive forced swimming stress in rats
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2015
url http://journalarticle.ukm.my/10355/1/44_1_21.pdf
http://journalarticle.ukm.my/10355/
http://www.mabjournal.com/index.php?option=com_content&view=article&id=520&catid=59:current-view&Itemid=56
_version_ 1643738091432706048
score 13.211869

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