Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation
Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA...
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Elsevier
2008
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| Online Access: | http://eprints.utm.my/7432/ http://dx.doi.org/10.1016/j.phymed.2007.08.002 |
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| author | Jantan, Ibrahim Raweh, Salwa M Sirat, Hasnah Mohd Jamil, Shajarahtunnur Mohd Yassin, Y.H Jalil, Juriyati Jamal, Jamia Azdina |
| author_facet | Jantan, Ibrahim Raweh, Salwa M Sirat, Hasnah Mohd Jamil, Shajarahtunnur Mohd Yassin, Y.H Jalil, Juriyati Jamal, Jamia Azdina |
| author_sort | Jantan, Ibrahim |
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| content_provider | Universiti Teknologi Malaysia |
| content_source | UTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from A. mutica and 3-deacetylcrotepoxide from K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC50 values of less than 84 μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC50 values of 37.5, 60.9 and 45.7 μM, respectively. |
| format | Article |
| id | my.utm.eprints-7432 |
| institution | Universiti Teknologi Malaysia |
| publishDate | 2008 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | my.utm.eprints-74322009-01-05T01:15:24Z http://eprints.utm.my/7432/ Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation Jantan, Ibrahim Raweh, Salwa M Sirat, Hasnah Mohd Jamil, Shajarahtunnur Mohd Yassin, Y.H Jalil, Juriyati Jamal, Jamia Azdina QD Chemistry Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from A. mutica and 3-deacetylcrotepoxide from K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC50 values of less than 84 μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC50 values of 37.5, 60.9 and 45.7 μM, respectively. Elsevier 2008-04-25 Article PeerReviewed Jantan, Ibrahim and Raweh, Salwa M and Sirat, Hasnah Mohd and Jamil, Shajarahtunnur and Mohd Yassin, Y.H and Jalil, Juriyati and Jamal, Jamia Azdina (2008) Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. Phytomedicine, 15 (4). pp. 306-309. ISSN 0944-7113 http://dx.doi.org/10.1016/j.phymed.2007.08.002 10.1016/j.phymed.2007.08.002 |
| spellingShingle | QD Chemistry Jantan, Ibrahim Raweh, Salwa M Sirat, Hasnah Mohd Jamil, Shajarahtunnur Mohd Yassin, Y.H Jalil, Juriyati Jamal, Jamia Azdina Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation |
| title | Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation |
| title_full | Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation |
| title_fullStr | Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation |
| title_full_unstemmed | Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation |
| title_short | Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation |
| title_sort | inhibitory effect of compounds from zingiberaceae species on human platelet aggregation |
| topic | QD Chemistry |
| url | http://eprints.utm.my/7432/ http://dx.doi.org/10.1016/j.phymed.2007.08.002 |
| url_provider | http://eprints.utm.my/ |