Synthesis of precursor of anti-cancer drugs
Highly reactive electrogenerated zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc was used for efficient transformation of et...
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| Format: | Conference or Workshop Item |
| Language: | en |
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2004
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| Online Access: | http://eprints.utm.my/5235/1/AishahAbdulJalil2004_SynthesisOfPrecursorOfAnti-cancerDrugs.pdf http://eprints.utm.my/5235/ |
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| _version_ | 1845471322499448832 |
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| author | Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao |
| author_facet | Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao |
| author_sort | Abdul Jalil, Aishah |
| building | UTM Library |
| collection | Institutional Repository |
| content_provider | Universiti Teknologi Malaysia |
| content_source | UTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Highly reactive electrogenerated zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc was used for efficient transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which was reacted with various aryl halides in the presence of palladium catalyst to give the corresponding cross-coupling products, ethyl 2-arylpropenoates, in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursors of non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen and ioxoprofen, which recently, have been shown to decrease the risk of cancer. |
| format | Conference or Workshop Item |
| id | my.utm.eprints-5235 |
| institution | Universiti Teknologi Malaysia |
| language | en |
| publishDate | 2004 |
| record_format | eprints |
| spelling | my.utm.eprints-52352017-09-10T06:41:09Z http://eprints.utm.my/5235/ Synthesis of precursor of anti-cancer drugs Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao T Technology (General) Highly reactive electrogenerated zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc was used for efficient transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which was reacted with various aryl halides in the presence of palladium catalyst to give the corresponding cross-coupling products, ethyl 2-arylpropenoates, in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursors of non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen and ioxoprofen, which recently, have been shown to decrease the risk of cancer. 2004 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.utm.my/5235/1/AishahAbdulJalil2004_SynthesisOfPrecursorOfAnti-cancerDrugs.pdf Abdul Jalil, Aishah and Kurono, Nobuhito and Tokuda, Masao (2004) Synthesis of precursor of anti-cancer drugs. In: Annual Fundamental Science Seminar 2004 (AFSS 2004), 14-15 June 2004, Ibnu Sina Institute for Fundamental Science Studies, UTM. (Submitted) |
| spellingShingle | T Technology (General) Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao Synthesis of precursor of anti-cancer drugs |
| title | Synthesis of precursor of anti-cancer drugs |
| title_full | Synthesis of precursor of anti-cancer drugs |
| title_fullStr | Synthesis of precursor of anti-cancer drugs |
| title_full_unstemmed | Synthesis of precursor of anti-cancer drugs |
| title_short | Synthesis of precursor of anti-cancer drugs |
| title_sort | synthesis of precursor of anti-cancer drugs |
| topic | T Technology (General) |
| url | http://eprints.utm.my/5235/1/AishahAbdulJalil2004_SynthesisOfPrecursorOfAnti-cancerDrugs.pdf http://eprints.utm.my/5235/ |
| url_provider | http://eprints.utm.my/ |