Enantiomer separation by enantioselective inclusion complexation-organic solvent nanofiltration
A novel chiral separation process, which utilizes a combination of enantioselective inclusion complexation (EIC) and organic solvent nanofiltration (OSN), was developed. Although EIC is an attractive way to resolve racemates, the difficulties associated with enantiomer recovery and chiral host recy...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
Elsevier
2006
|
| Subjects: | |
| Online Access: | http://eprints.utm.my/419/1/nazlee_Tetra.pdf http://eprints.utm.my/419/ http://dx.doi.org/10.1016/j.tetasy.2006.06.026 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1845470275728048128 |
|---|---|
| author | Ghazali, Nazlee Faisal Ferreira, Frederico C. White, Andrew J. P. Livingston, Andrew |
| author_facet | Ghazali, Nazlee Faisal Ferreira, Frederico C. White, Andrew J. P. Livingston, Andrew |
| author_sort | Ghazali, Nazlee Faisal |
| building | UTM Library |
| collection | Institutional Repository |
| content_provider | Universiti Teknologi Malaysia |
| content_source | UTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | A novel chiral separation process, which utilizes a combination of enantioselective inclusion complexation (EIC) and organic solvent nanofiltration (OSN), was developed. Although EIC is an attractive way to resolve racemates, the difficulties associated with
enantiomer recovery and chiral host recycle has limited large-scale applications. EIC coupled with OSN replaces distillation for the recovery of enantiomers from enantioenriched solid complex. A decomplexation solvent is employed to dissociate enantiomers from the complex, and subsequent separation of enantiomers from the chiral host is realized using OSN. The new process was investigated using racemic 1-phenylethanol as the guest and (R,R)-TADDOL as the chiral host. This novel technology expands the application of EIC to the resolution of nonvolatile racemates , and enables large-scale application. |
| format | Article |
| id | my.utm.eprints-419 |
| institution | Universiti Teknologi Malaysia |
| language | en |
| publishDate | 2006 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | my.utm.eprints-4192017-08-28T02:46:51Z http://eprints.utm.my/419/ Enantiomer separation by enantioselective inclusion complexation-organic solvent nanofiltration Ghazali, Nazlee Faisal Ferreira, Frederico C. White, Andrew J. P. Livingston, Andrew TP Chemical technology A novel chiral separation process, which utilizes a combination of enantioselective inclusion complexation (EIC) and organic solvent nanofiltration (OSN), was developed. Although EIC is an attractive way to resolve racemates, the difficulties associated with enantiomer recovery and chiral host recycle has limited large-scale applications. EIC coupled with OSN replaces distillation for the recovery of enantiomers from enantioenriched solid complex. A decomplexation solvent is employed to dissociate enantiomers from the complex, and subsequent separation of enantiomers from the chiral host is realized using OSN. The new process was investigated using racemic 1-phenylethanol as the guest and (R,R)-TADDOL as the chiral host. This novel technology expands the application of EIC to the resolution of nonvolatile racemates , and enables large-scale application. Elsevier 2006-06-16 Article PeerReviewed application/pdf en http://eprints.utm.my/419/1/nazlee_Tetra.pdf Ghazali, Nazlee Faisal and Ferreira, Frederico C. and White, Andrew J. P. and Livingston, Andrew (2006) Enantiomer separation by enantioselective inclusion complexation-organic solvent nanofiltration. Tetrahedron: Asymmetry, 17 (2). pp. 1846-1852. ISSN 0957-4166 http://dx.doi.org/10.1016/j.tetasy.2006.06.026 10.1016/j.tetasy.2006.06.026 |
| spellingShingle | TP Chemical technology Ghazali, Nazlee Faisal Ferreira, Frederico C. White, Andrew J. P. Livingston, Andrew Enantiomer separation by enantioselective inclusion complexation-organic solvent nanofiltration |
| title | Enantiomer separation by enantioselective inclusion
complexation-organic solvent nanofiltration |
| title_full | Enantiomer separation by enantioselective inclusion
complexation-organic solvent nanofiltration |
| title_fullStr | Enantiomer separation by enantioselective inclusion
complexation-organic solvent nanofiltration |
| title_full_unstemmed | Enantiomer separation by enantioselective inclusion
complexation-organic solvent nanofiltration |
| title_short | Enantiomer separation by enantioselective inclusion
complexation-organic solvent nanofiltration |
| title_sort | enantiomer separation by enantioselective inclusion
complexation-organic solvent nanofiltration |
| topic | TP Chemical technology |
| url | http://eprints.utm.my/419/1/nazlee_Tetra.pdf http://eprints.utm.my/419/ http://dx.doi.org/10.1016/j.tetasy.2006.06.026 |
| url_provider | http://eprints.utm.my/ |