Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding
Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet-activating factor (PAF) antagonistic activities on rabbit platelets using 3H-PAF as a ligand. Among them, four compounds showed signi...
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John Wiley & Sons, Ltd
2004
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| Online Access: | http://eprints.utm.my/2926/ http://dx.doi.org/10.1002/ptr.1608 |
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| author | Jantan, Ibrahim Pisar, Mazura Mohd. Sirat, Hasnah Basar, Norazah Jamil, Shajarahtunnur Mat Ali, Rasadah Jalil, Juriyati |
| author_facet | Jantan, Ibrahim Pisar, Mazura Mohd. Sirat, Hasnah Basar, Norazah Jamil, Shajarahtunnur Mat Ali, Rasadah Jalil, Juriyati |
| author_sort | Jantan, Ibrahim |
| building | UTM Library |
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| content_provider | Universiti Teknologi Malaysia |
| content_source | UTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet-activating factor (PAF) antagonistic activities on rabbit platelets using 3H-PAF as a ligand. Among them, four compounds showed significant inhibitory effects. Alpinetin and 5,6-dehydrokawain isolated from A. mutica exhibited IC50 values of 41.6 and 59.3 µm, respectively. The IC50 values of 3-deacetylcrotepoxide and 2-hydroxy-4,4,6-trimethoxychalcone from K. rotunda were 45.6 and 57.4 µM, respectively. 1-Methoxy-2-methyl-5-(1,5-dimethylhex-4-enyl)-benzene, synthesized by methylation of xanthorrhizol which was obtained from C. xanthorrhiza, showed an IC50 value of 40.9 µm. The results indicated that these compounds were relatively strong PAF receptor binding inhibitors |
| format | Article |
| id | my.utm.eprints-2926 |
| institution | Universiti Teknologi Malaysia |
| publishDate | 2004 |
| publisher | John Wiley & Sons, Ltd |
| record_format | eprints |
| spelling | my.utm.eprints-29262017-05-14T07:46:14Z http://eprints.utm.my/2926/ Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding Jantan, Ibrahim Pisar, Mazura Mohd. Sirat, Hasnah Basar, Norazah Jamil, Shajarahtunnur Mat Ali, Rasadah Jalil, Juriyati QD Chemistry Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet-activating factor (PAF) antagonistic activities on rabbit platelets using 3H-PAF as a ligand. Among them, four compounds showed significant inhibitory effects. Alpinetin and 5,6-dehydrokawain isolated from A. mutica exhibited IC50 values of 41.6 and 59.3 µm, respectively. The IC50 values of 3-deacetylcrotepoxide and 2-hydroxy-4,4,6-trimethoxychalcone from K. rotunda were 45.6 and 57.4 µM, respectively. 1-Methoxy-2-methyl-5-(1,5-dimethylhex-4-enyl)-benzene, synthesized by methylation of xanthorrhizol which was obtained from C. xanthorrhiza, showed an IC50 value of 40.9 µm. The results indicated that these compounds were relatively strong PAF receptor binding inhibitors John Wiley & Sons, Ltd 2004-12 Article PeerReviewed Jantan, Ibrahim and Pisar, Mazura and Mohd. Sirat, Hasnah and Basar, Norazah and Jamil, Shajarahtunnur and Mat Ali, Rasadah and Jalil, Juriyati (2004) Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. Phytotherapy Research , 18 (12). pp. 1005-1007. ISSN 0951-418X http://dx.doi.org/10.1002/ptr.1608 doi:10.1002/ptr.1608 |
| spellingShingle | QD Chemistry Jantan, Ibrahim Pisar, Mazura Mohd. Sirat, Hasnah Basar, Norazah Jamil, Shajarahtunnur Mat Ali, Rasadah Jalil, Juriyati Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding |
| title | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding |
| title_full | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding |
| title_fullStr | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding |
| title_full_unstemmed | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding |
| title_short | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding |
| title_sort | inhibitory effects of compounds from zingiberaceae species on platelet activating factor receptor binding |
| topic | QD Chemistry |
| url | http://eprints.utm.my/2926/ http://dx.doi.org/10.1002/ptr.1608 |
| url_provider | http://eprints.utm.my/ |