Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials
Dry bacterial cellulose nanofiber (BC) sheet coated with poly(lactic acid) (PLA) was developed and characterized towards acute wound healing applications. This new approach of PLA coating on BC revealed enhanced physical and antibacterial properties. Commercial BC sheets originated from the manufact...
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| Language: | en |
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2018
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| Online Access: | http://eprints.uthm.edu.my/5048/1/AJ%202018%20%28825%29%20Influence%20of%20poly%28lactic%20acid%29%20layer%20on%20the%20physical%20and%20antibacterial%20properties%20Of%20dry%20bacterial%20cellulose%20sheet%20for%20potential%20acute%20w.pdf http://eprints.uthm.edu.my/5048/ |
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| author | Yee, Foong Choi Anwar Hamzah, Mohd Syahir Abd Razak, Saiful Izwan Saidin, Syafiqah Mat Nayan, Nadirul Hasraf |
| author_facet | Yee, Foong Choi Anwar Hamzah, Mohd Syahir Abd Razak, Saiful Izwan Saidin, Syafiqah Mat Nayan, Nadirul Hasraf |
| author_sort | Yee, Foong Choi |
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| content_provider | Universiti Tun Hussein Onn Malaysia |
| content_source | UTHM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Dry bacterial cellulose nanofiber (BC) sheet coated with poly(lactic acid) (PLA) was developed and characterized towards acute wound healing applications. This new approach of PLA coating on BC revealed enhanced physical and antibacterial properties. Commercial BC sheets originated from the manufacturing of nata de coco jelly were dried and coated with the PLA at various concentrations of 2, 4, 6, 8, 10 and 12 % w/v for the purpose of improving the mechanical properties and followed by loading of antiseptic such as benzalkonium chloride (BAC). PLA has been proposed for the use of coating materials at a concentration of 8 %, the biocomposite sheet started exhibiting a low moisture uptake, prolonged swelling in simulated wound fluid solution and high tear (9.17 Nm2 /kg) and burst indices (32.5 kPa·m2 /g). The 8 % PLA coating revealed porous fiber-like morphology as observed under scanning electron microscope. Therapeutic loading capacity of the BC/8 PLA was substantially higher than the pristine BC. Furthermore strong antimicrobial activities against Staphylococcus aureaus and Escherichia coli were observed for the BC/8PLA biocomposite film. These reports were clearly suggestive of the fact that synthetic biodegradable polymers, such as PLA, may be exploited for the synergistic combination with BC for antimicrobial and acute wound management. This new and modified fiber source material could reduce the dependency on plant based cellulose for more demanding biomedical applications such as wound healing materials, vascular graft, cartilage replacement, drug delivery and tissue engineering. |
| format | Article |
| id | my.uthm.eprints-5048 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | en |
| publishDate | 2018 |
| publisher | Springer |
| record_format | eprints |
| spelling | my.uthm.eprints-50482022-01-04T07:13:59Z http://eprints.uthm.edu.my/5048/ Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials Yee, Foong Choi Anwar Hamzah, Mohd Syahir Abd Razak, Saiful Izwan Saidin, Syafiqah Mat Nayan, Nadirul Hasraf TP Chemical technology TP248.13-248.65 Biotechnology Dry bacterial cellulose nanofiber (BC) sheet coated with poly(lactic acid) (PLA) was developed and characterized towards acute wound healing applications. This new approach of PLA coating on BC revealed enhanced physical and antibacterial properties. Commercial BC sheets originated from the manufacturing of nata de coco jelly were dried and coated with the PLA at various concentrations of 2, 4, 6, 8, 10 and 12 % w/v for the purpose of improving the mechanical properties and followed by loading of antiseptic such as benzalkonium chloride (BAC). PLA has been proposed for the use of coating materials at a concentration of 8 %, the biocomposite sheet started exhibiting a low moisture uptake, prolonged swelling in simulated wound fluid solution and high tear (9.17 Nm2 /kg) and burst indices (32.5 kPa·m2 /g). The 8 % PLA coating revealed porous fiber-like morphology as observed under scanning electron microscope. Therapeutic loading capacity of the BC/8 PLA was substantially higher than the pristine BC. Furthermore strong antimicrobial activities against Staphylococcus aureaus and Escherichia coli were observed for the BC/8PLA biocomposite film. These reports were clearly suggestive of the fact that synthetic biodegradable polymers, such as PLA, may be exploited for the synergistic combination with BC for antimicrobial and acute wound management. This new and modified fiber source material could reduce the dependency on plant based cellulose for more demanding biomedical applications such as wound healing materials, vascular graft, cartilage replacement, drug delivery and tissue engineering. Springer 2018 Article PeerReviewed text en http://eprints.uthm.edu.my/5048/1/AJ%202018%20%28825%29%20Influence%20of%20poly%28lactic%20acid%29%20layer%20on%20the%20physical%20and%20antibacterial%20properties%20Of%20dry%20bacterial%20cellulose%20sheet%20for%20potential%20acute%20w.pdf Yee, Foong Choi and Anwar Hamzah, Mohd Syahir and Abd Razak, Saiful Izwan and Saidin, Syafiqah and Mat Nayan, Nadirul Hasraf (2018) Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials. FIBERS AND POLYMERS, 19 (2). pp. 263-271. ISSN 1229-9197 |
| spellingShingle | TP Chemical technology TP248.13-248.65 Biotechnology Yee, Foong Choi Anwar Hamzah, Mohd Syahir Abd Razak, Saiful Izwan Saidin, Syafiqah Mat Nayan, Nadirul Hasraf Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials |
| title | Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials |
| title_full | Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials |
| title_fullStr | Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials |
| title_full_unstemmed | Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials |
| title_short | Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials |
| title_sort | influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials |
| topic | TP Chemical technology TP248.13-248.65 Biotechnology |
| url | http://eprints.uthm.edu.my/5048/1/AJ%202018%20%28825%29%20Influence%20of%20poly%28lactic%20acid%29%20layer%20on%20the%20physical%20and%20antibacterial%20properties%20Of%20dry%20bacterial%20cellulose%20sheet%20for%20potential%20acute%20w.pdf http://eprints.uthm.edu.my/5048/ |
| url_provider | http://eprints.uthm.edu.my/ |