Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design
Biodegradation of pharmaceuticals active compounds (PACs) in secondary effluents by using B. subtilis 2012WTNC as a function of β-lactamase was optimized using response surface methodology (RSM) designed by central composite design (CCD). Four factors including initial concentration of bacteria (1–6...
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Elsevier
2019
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| Online Access: | http://eprints.uthm.edu.my/4105/1/AJ%202019%20%28233%29.pdf http://eprints.uthm.edu.my/4105/ https://doi.org/10.1016/j.jhazmat.2018.11.068 |
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| author | Al-Gheethi, Adel Noman, Efaq Radin Mohamed, Radin Maya Saphira Ismail, Norli Abdullah, Abd Halid Mohd Kassim, Amir Hashim |
| author_facet | Al-Gheethi, Adel Noman, Efaq Radin Mohamed, Radin Maya Saphira Ismail, Norli Abdullah, Abd Halid Mohd Kassim, Amir Hashim |
| author_sort | Al-Gheethi, Adel |
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| content_provider | Universiti Tun Hussein Onn Malaysia |
| content_source | UTHM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Biodegradation of pharmaceuticals active compounds (PACs) in secondary effluents by using B. subtilis 2012WTNC as a function of β-lactamase was optimized using response surface methodology (RSM) designed by central composite design (CCD). Four factors including initial concentration of bacteria (1–6 log10 CFU mL−1), incubation period (1–14 days), incubation temperature (20–40 °C) and initial concentration of PACs (1–5mg L−1) were investigated. The optimal operating factors for biodegradation process determined using response surface methodology (RSM) was recorded with 5.57 log10 CFU mL−1 of B. subtilis, for 10.38 days, at 36.62 °C and with 4.14 mg L−1 of (cephalexin/amoxicillin) with R2 coefficient of 0.99. The biodegradation was 83.81 and 93.94% respectively. The relationship among the independent variables was significant (p < 0.05) with 95% of confidence level at the best operating parameters. The bioassay for PACs after the degradation |
| format | Article |
| id | my.uthm.eprints-4105 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | en |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | my.uthm.eprints-41052021-11-25T03:31:40Z http://eprints.uthm.edu.my/4105/ Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design Al-Gheethi, Adel Noman, Efaq Radin Mohamed, Radin Maya Saphira Ismail, Norli Abdullah, Abd Halid Mohd Kassim, Amir Hashim TP200-248 Chemicals: Manufacture, use, etc. Biodegradation of pharmaceuticals active compounds (PACs) in secondary effluents by using B. subtilis 2012WTNC as a function of β-lactamase was optimized using response surface methodology (RSM) designed by central composite design (CCD). Four factors including initial concentration of bacteria (1–6 log10 CFU mL−1), incubation period (1–14 days), incubation temperature (20–40 °C) and initial concentration of PACs (1–5mg L−1) were investigated. The optimal operating factors for biodegradation process determined using response surface methodology (RSM) was recorded with 5.57 log10 CFU mL−1 of B. subtilis, for 10.38 days, at 36.62 °C and with 4.14 mg L−1 of (cephalexin/amoxicillin) with R2 coefficient of 0.99. The biodegradation was 83.81 and 93.94% respectively. The relationship among the independent variables was significant (p < 0.05) with 95% of confidence level at the best operating parameters. The bioassay for PACs after the degradation Elsevier 2019 Article PeerReviewed text en http://eprints.uthm.edu.my/4105/1/AJ%202019%20%28233%29.pdf Al-Gheethi, Adel and Noman, Efaq and Radin Mohamed, Radin Maya Saphira and Ismail, Norli and Abdullah, Abd Halid and Mohd Kassim, Amir Hashim (2019) Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design. Journal of Hazardous Materials, 365. pp. 883-894. ISSN 0304-3894 https://doi.org/10.1016/j.jhazmat.2018.11.068 |
| spellingShingle | TP200-248 Chemicals: Manufacture, use, etc. Al-Gheethi, Adel Noman, Efaq Radin Mohamed, Radin Maya Saphira Ismail, Norli Abdullah, Abd Halid Mohd Kassim, Amir Hashim Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design |
| title | Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design |
| title_full | Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design |
| title_fullStr | Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design |
| title_full_unstemmed | Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design |
| title_short | Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from Bacillus subtilis using central composite design |
| title_sort | optimizing of pharmaceutical active compounds biodegradability in secondary effluents by β-lactamase from bacillus subtilis using central composite design |
| topic | TP200-248 Chemicals: Manufacture, use, etc. |
| url | http://eprints.uthm.edu.my/4105/1/AJ%202019%20%28233%29.pdf http://eprints.uthm.edu.my/4105/ https://doi.org/10.1016/j.jhazmat.2018.11.068 |
| url_provider | http://eprints.uthm.edu.my/ |