Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications
Psychrophiles are cold-living microorganisms synthesizing enzymes that are permanently active at almost near-zero temperatures. Psychrozymes are supposed to be structurally more flexible than their homologous proteins. This structural flexibility enables these proteins to undergo conformational ch...
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| Format: | Article |
| Language: | en |
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Springer
2020
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| Online Access: | http://eprints.uthm.edu.my/1081/1/J11981_3009d433f18f8d8e028012afd91a81c2.pdf http://eprints.uthm.edu.my/1081/ https://doi.org/10.1007/s00253-020-11074-0 |
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| author | Parvizpour, Sepideh Hussin, Nurulfarhana Shamsir, Mohd Shahir Razmara, Jafar |
| author_facet | Parvizpour, Sepideh Hussin, Nurulfarhana Shamsir, Mohd Shahir Razmara, Jafar |
| author_sort | Parvizpour, Sepideh |
| building | UTHM Library |
| collection | Institutional Repository |
| content_provider | Universiti Tun Hussein Onn Malaysia |
| content_source | UTHM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Psychrophiles are cold-living microorganisms synthesizing enzymes that are permanently active at almost near-zero temperatures.
Psychrozymes are supposed to be structurally more flexible than their homologous proteins. This structural flexibility
enables these proteins to undergo conformational changes during catalysis and improve catalytic efficiency at low temperatures.
The outstanding characteristics of the psychrophilic enzymes have attracted the attention of the scientific community to utilize
them in a wide variety of industrial and pharmaceutical applications. In this review, we first highlight the current knowledge of
the cold-adaptation mechanisms of the psychrophiles. In the sequel, we describe the potential applications of the enzymes in
different biotechnological processes specifically, in the production of industrial and pharmaceutical products. |
| format | Article |
| id | my.uthm.eprints-1081 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | en |
| publishDate | 2020 |
| publisher | Springer |
| record_format | eprints |
| spelling | my.uthm.eprints-10812021-10-17T07:36:29Z http://eprints.uthm.edu.my/1081/ Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications Parvizpour, Sepideh Hussin, Nurulfarhana Shamsir, Mohd Shahir Razmara, Jafar QR Microbiology Psychrophiles are cold-living microorganisms synthesizing enzymes that are permanently active at almost near-zero temperatures. Psychrozymes are supposed to be structurally more flexible than their homologous proteins. This structural flexibility enables these proteins to undergo conformational changes during catalysis and improve catalytic efficiency at low temperatures. The outstanding characteristics of the psychrophilic enzymes have attracted the attention of the scientific community to utilize them in a wide variety of industrial and pharmaceutical applications. In this review, we first highlight the current knowledge of the cold-adaptation mechanisms of the psychrophiles. In the sequel, we describe the potential applications of the enzymes in different biotechnological processes specifically, in the production of industrial and pharmaceutical products. Springer 2020 Article PeerReviewed text en http://eprints.uthm.edu.my/1081/1/J11981_3009d433f18f8d8e028012afd91a81c2.pdf Parvizpour, Sepideh and Hussin, Nurulfarhana and Shamsir, Mohd Shahir and Razmara, Jafar (2020) Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-020-11074-0 |
| spellingShingle | QR Microbiology Parvizpour, Sepideh Hussin, Nurulfarhana Shamsir, Mohd Shahir Razmara, Jafar Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications |
| title | Psychrophilic enzymes: structural adaptation, pharmaceutical
and industrial applications |
| title_full | Psychrophilic enzymes: structural adaptation, pharmaceutical
and industrial applications |
| title_fullStr | Psychrophilic enzymes: structural adaptation, pharmaceutical
and industrial applications |
| title_full_unstemmed | Psychrophilic enzymes: structural adaptation, pharmaceutical
and industrial applications |
| title_short | Psychrophilic enzymes: structural adaptation, pharmaceutical
and industrial applications |
| title_sort | psychrophilic enzymes: structural adaptation, pharmaceutical
and industrial applications |
| topic | QR Microbiology |
| url | http://eprints.uthm.edu.my/1081/1/J11981_3009d433f18f8d8e028012afd91a81c2.pdf http://eprints.uthm.edu.my/1081/ https://doi.org/10.1007/s00253-020-11074-0 |
| url_provider | http://eprints.uthm.edu.my/ |