The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model
The tumor necrosis factor receptor 2 (TNFR2) has been implicated in cancerrelated inflammation and immune responses, yet its role in breast cancer remains unclear. This study aimed to explore the effect of Tamoxifen (TAM) on TNFR2 expression in an N-methyl-N-nitrosourea (NMU)-induced breast cance...
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| Format: | Thesis |
| Language: | en |
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2025
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| Online Access: | http://eprints.usm.my/62839/1/ROS%20AKMAL%20BINTI%20MOHD%20IDRIS-TESIS%20P-UM002021%28R%29-E.pdf http://eprints.usm.my/62839/ |
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| _version_ | 1854094238367612928 |
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| author | Idris, Ros Akmal Mohd |
| author_facet | Idris, Ros Akmal Mohd |
| author_sort | Idris, Ros Akmal Mohd |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | The tumor necrosis factor receptor 2 (TNFR2) has been implicated in cancerrelated
inflammation and immune responses, yet its role in breast cancer remains
unclear. This study aimed to explore the effect of Tamoxifen (TAM) on TNFR2
expression in an N-methyl-N-nitrosourea (NMU)-induced breast cancer rat model, as
well as others associated biomarkers (ER, PR, HER2, Bax, Bcl-2). Rats were divided
into three groups: healthy controls, NMU-induced positive group, and NMU-induced
group treated with TAM. Immunohistochemistry (IHC) was performed to assess
biomarkers expression. Results showed that TNFR2 was undetectable in both the
Positive and TAM-treated groups, suggesting that TNFR2 may not play a significant
role in this NMU-induced breast cancer model. ER and PR levels were found to
decrease after TAM treatment, indicating TAM's influence on hormonal receptor
signalling in this model. HER2 expression was almost undetectable across all groups,
while Bax, a pro-apoptotic marker, showed reduced expression in the positive group
meanwhile TAM group shows moderate expression. In contrast, Bcl-2, an antiapoptotic
protein, displayed varied expression patterns across the groups. These
findings suggest that TAM impacts hormonal receptor signalling and apoptosis
regulation but does not appear to influence TNFR2 expression in this NMU-induced
breast cancer rat model. This is the first study that investigating the role of TNFR2
with others associated markers in NMU-induced breast cancer rat model. |
| format | Thesis |
| id | my.usm.eprints.62839 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2025 |
| record_format | eprints |
| spelling | my.usm.eprints.62839 http://eprints.usm.my/62839/ The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model Idris, Ros Akmal Mohd R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) The tumor necrosis factor receptor 2 (TNFR2) has been implicated in cancerrelated inflammation and immune responses, yet its role in breast cancer remains unclear. This study aimed to explore the effect of Tamoxifen (TAM) on TNFR2 expression in an N-methyl-N-nitrosourea (NMU)-induced breast cancer rat model, as well as others associated biomarkers (ER, PR, HER2, Bax, Bcl-2). Rats were divided into three groups: healthy controls, NMU-induced positive group, and NMU-induced group treated with TAM. Immunohistochemistry (IHC) was performed to assess biomarkers expression. Results showed that TNFR2 was undetectable in both the Positive and TAM-treated groups, suggesting that TNFR2 may not play a significant role in this NMU-induced breast cancer model. ER and PR levels were found to decrease after TAM treatment, indicating TAM's influence on hormonal receptor signalling in this model. HER2 expression was almost undetectable across all groups, while Bax, a pro-apoptotic marker, showed reduced expression in the positive group meanwhile TAM group shows moderate expression. In contrast, Bcl-2, an antiapoptotic protein, displayed varied expression patterns across the groups. These findings suggest that TAM impacts hormonal receptor signalling and apoptosis regulation but does not appear to influence TNFR2 expression in this NMU-induced breast cancer rat model. This is the first study that investigating the role of TNFR2 with others associated markers in NMU-induced breast cancer rat model. 2025-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/62839/1/ROS%20AKMAL%20BINTI%20MOHD%20IDRIS-TESIS%20P-UM002021%28R%29-E.pdf Idris, Ros Akmal Mohd (2025) The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Idris, Ros Akmal Mohd The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model |
| title | The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model |
| title_full | The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model |
| title_fullStr | The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model |
| title_full_unstemmed | The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model |
| title_short | The effects of tamoxifen on TNFR2 in NMU-induced breast cancer rat model |
| title_sort | effects of tamoxifen on tnfr2 in nmu-induced breast cancer rat model |
| topic | R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.usm.my/62839/1/ROS%20AKMAL%20BINTI%20MOHD%20IDRIS-TESIS%20P-UM002021%28R%29-E.pdf http://eprints.usm.my/62839/ |
| url_provider | http://eprints.usm.my/ |