Study on the gjb3 and gjb6 gene mutations among Malays with nonsyndromic hearing loss
Hearing loss is the most common sensory disorder in human. Previous journals reported that GJB2 gene is the most important gene involved in non-syndromic hearing loss; and GJB6 gene is the second most which contributed to. This study is to screen mutations in GJB2 and GJB6 gene among Malay patien...
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| Format: | Article |
| Language: | en |
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Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia
2009
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| Online Access: | http://eprints.usm.my/48691/1/DR.%20MOHD%20KHAIRI%20MD%20DAUD-OCR.pdf http://eprints.usm.my/48691/ |
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| _version_ | 1834504187224784896 |
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| author | Daud, Mohd Khairi Md Rahman, Normastura Abd Zainuddin, Zafarina |
| author_facet | Daud, Mohd Khairi Md Rahman, Normastura Abd Zainuddin, Zafarina |
| author_sort | Daud, Mohd Khairi Md |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Hearing loss is the most common sensory disorder in human. Previous journals reported that
GJB2 gene is the most important gene involved in non-syndromic hearing loss; and GJB6 gene is
the second most which contributed to. This study is to screen mutations in GJB2 and GJB6 gene
among Malay patients with non-syndromic hearing loss. Ninety one patients and equal number
of normal hearing subjects were recruited for this study after getting informed consent. DNA
samples were collected using sterile buccal swab. After DNA extraction, genomic DNA was
amplified then screened using dHPLC technique. Certain samples were sequenced to confirm the
type of mutation. The result showed that only a few samples having mutations in GJB2 gene,
while no sample having mutation of GJB6 gene. |
| format | Article |
| id | my.usm.eprints.48691 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2009 |
| publisher | Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia |
| record_format | eprints |
| spelling | my.usm.eprints.48691 http://eprints.usm.my/48691/ Study on the gjb3 and gjb6 gene mutations among Malays with nonsyndromic hearing loss Daud, Mohd Khairi Md Rahman, Normastura Abd Zainuddin, Zafarina R Medicine Hearing loss is the most common sensory disorder in human. Previous journals reported that GJB2 gene is the most important gene involved in non-syndromic hearing loss; and GJB6 gene is the second most which contributed to. This study is to screen mutations in GJB2 and GJB6 gene among Malay patients with non-syndromic hearing loss. Ninety one patients and equal number of normal hearing subjects were recruited for this study after getting informed consent. DNA samples were collected using sterile buccal swab. After DNA extraction, genomic DNA was amplified then screened using dHPLC technique. Certain samples were sequenced to confirm the type of mutation. The result showed that only a few samples having mutations in GJB2 gene, while no sample having mutation of GJB6 gene. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2009 Article NonPeerReviewed application/pdf en http://eprints.usm.my/48691/1/DR.%20MOHD%20KHAIRI%20MD%20DAUD-OCR.pdf Daud, Mohd Khairi Md and Rahman, Normastura Abd and Zainuddin, Zafarina (2009) Study on the gjb3 and gjb6 gene mutations among Malays with nonsyndromic hearing loss. Study on the gjb3 and gjb6 gene mutations among Malays with nonsyndromic hearing loss. (Submitted) |
| spellingShingle | R Medicine Daud, Mohd Khairi Md Rahman, Normastura Abd Zainuddin, Zafarina Study on the gjb3 and gjb6 gene mutations among Malays with nonsyndromic hearing loss |
| title | Study on the gjb3 and gjb6 gene
mutations among Malays with nonsyndromic
hearing loss |
| title_full | Study on the gjb3 and gjb6 gene
mutations among Malays with nonsyndromic
hearing loss |
| title_fullStr | Study on the gjb3 and gjb6 gene
mutations among Malays with nonsyndromic
hearing loss |
| title_full_unstemmed | Study on the gjb3 and gjb6 gene
mutations among Malays with nonsyndromic
hearing loss |
| title_short | Study on the gjb3 and gjb6 gene
mutations among Malays with nonsyndromic
hearing loss |
| title_sort | study on the gjb3 and gjb6 gene
mutations among malays with nonsyndromic
hearing loss |
| topic | R Medicine |
| url | http://eprints.usm.my/48691/1/DR.%20MOHD%20KHAIRI%20MD%20DAUD-OCR.pdf http://eprints.usm.my/48691/ |
| url_provider | http://eprints.usm.my/ |