Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats
Research has been conducted on standardised aqueous extract of Kacip Fatimah or Labisia pumilar (var. alata), commercially known as Biolabisia., on the reproductive, developmental and female toxicity in Sprague Dawley rats. Results obtained indicated that the administration of Biolabisia"�...
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| Format: | Monograph |
| Language: | en |
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Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia
2009
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| Online Access: | http://eprints.usm.my/48687/1/PROF%20MADYA%20SITI%20AMRAH%20SULAIMAN-OCR.pdf http://eprints.usm.my/48687/ |
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| _version_ | 1834504186089177088 |
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| author | Sulaiman, Siti Amrah |
| author_facet | Sulaiman, Siti Amrah |
| author_sort | Sulaiman, Siti Amrah |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Research has been conducted on standardised aqueous extract of Kacip
Fatimah or Labisia pumilar (var. alata), commercially known as Biolabisia., on the
reproductive, developmental and female toxicity in Sprague Dawley rats. Results
obtained indicated that the administration of Biolabisia"' up to 1000 mg/kg/day did not
cause mortality nor show noticeably any treatment-related signs of toxicity on the
physical appearance and behaviour of all the rats studied. There was a consistent
trend of less weight gain noted in all the herbal treated group animals. Treatment with
Biolabisia® to pregnant rats did not result in significant foetal loss or any congenital
malformations. The duration of oestrous cycles and reproductive organs weight of rats
were statistically unaffected by Biolabisia"', however the increase number of rats with
irregular cycles, presence of polycystic ovaries and increasing trends in progesterone
and free testosterone hormonal levels in animals that received 1000 mg/kg/day
Biolabisia., raised a little concern. Taking all the cumulative data together, the current
findings suggest that oral treatment of Biolabisia., up to 1000 mg/kg/day in female rats
is not associated with significant deleterious effects in reproductive parameters in rats.
However, body weight and estrous cycle of the females could be affected if Biolabisia"'
is administered at a very high dose and for a longer duration. These could be due to
the androgenic effects of the herb in rats. |
| format | Monograph |
| id | my.usm.eprints.48687 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2009 |
| publisher | Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia |
| record_format | eprints |
| spelling | my.usm.eprints.48687 http://eprints.usm.my/48687/ Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats Sulaiman, Siti Amrah R Medicine Research has been conducted on standardised aqueous extract of Kacip Fatimah or Labisia pumilar (var. alata), commercially known as Biolabisia., on the reproductive, developmental and female toxicity in Sprague Dawley rats. Results obtained indicated that the administration of Biolabisia"' up to 1000 mg/kg/day did not cause mortality nor show noticeably any treatment-related signs of toxicity on the physical appearance and behaviour of all the rats studied. There was a consistent trend of less weight gain noted in all the herbal treated group animals. Treatment with Biolabisia® to pregnant rats did not result in significant foetal loss or any congenital malformations. The duration of oestrous cycles and reproductive organs weight of rats were statistically unaffected by Biolabisia"', however the increase number of rats with irregular cycles, presence of polycystic ovaries and increasing trends in progesterone and free testosterone hormonal levels in animals that received 1000 mg/kg/day Biolabisia., raised a little concern. Taking all the cumulative data together, the current findings suggest that oral treatment of Biolabisia., up to 1000 mg/kg/day in female rats is not associated with significant deleterious effects in reproductive parameters in rats. However, body weight and estrous cycle of the females could be affected if Biolabisia"' is administered at a very high dose and for a longer duration. These could be due to the androgenic effects of the herb in rats. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2009 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/48687/1/PROF%20MADYA%20SITI%20AMRAH%20SULAIMAN-OCR.pdf Sulaiman, Siti Amrah (2009) Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats. Other. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine Sulaiman, Siti Amrah Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats |
| title | Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats |
| title_full | Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats |
| title_fullStr | Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats |
| title_full_unstemmed | Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats |
| title_short | Reproductive toxicity and teratogenicity studies of Kacip fatimah (Labisia pumila) in rats |
| title_sort | reproductive toxicity and teratogenicity studies of kacip fatimah (labisia pumila) in rats |
| topic | R Medicine |
| url | http://eprints.usm.my/48687/1/PROF%20MADYA%20SITI%20AMRAH%20SULAIMAN-OCR.pdf http://eprints.usm.my/48687/ |
| url_provider | http://eprints.usm.my/ |