Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were scr...
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| Format: | Thesis |
| Language: | en |
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2013
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| Online Access: | http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf http://eprints.usm.my/46191/ |
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| _version_ | 1834503532741394432 |
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| author | Mohammed, Omar Saeed Ali |
| author_facet | Mohammed, Omar Saeed Ali |
| author_sort | Mohammed, Omar Saeed Ali |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated. |
| format | Thesis |
| id | my.usm.eprints.46191 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2013 |
| record_format | eprints |
| spelling | my.usm.eprints.46191 http://eprints.usm.my/46191/ Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia Mohammed, Omar Saeed Ali RK1-715 Dentistry The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated. 2013-11 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf Mohammed, Omar Saeed Ali (2013) Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RK1-715 Dentistry Mohammed, Omar Saeed Ali Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_full | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_fullStr | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_full_unstemmed | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_short | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_sort | anti-neoplastic studies of standardized root extract of eurycomal longifolia (taf273) towards leukaemia |
| topic | RK1-715 Dentistry |
| url | http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf http://eprints.usm.my/46191/ |
| url_provider | http://eprints.usm.my/ |