Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein
The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported...
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| Format: | Thesis |
| Language: | en |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://eprints.usm.my/45074/1/TEOW%20SIN%20YEANG.pdf http://eprints.usm.my/45074/ |
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| Summary: | The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells. However, the peptides are less stable in the blood, thus resulting in rapid clearance from the system and they can exhibit off-target activities. Monoclonal antibodies (MAbs) on the other hand, are stable and highly specific molecule, |
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