Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies
Twenty percent of the genes from Klebsiella pneumonaie MGH78578 coded for hypothetical protein. Two particular hypothetical proteins KPN00728 and KPN00729 were identified using bioinformatics approaches. Both open reading frames showed high sequence homology to succinate dehydrogenase Chain C (SdhC)...
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| Format: | Thesis |
| Language: | en |
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2011
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| Online Access: | http://eprints.usm.my/43236/1/CHOI%20SY%20BING.pdf http://eprints.usm.my/43236/ |
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| _version_ | 1834502778186104832 |
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| author | Choi, Sy Bing |
| author_facet | Choi, Sy Bing |
| author_sort | Choi, Sy Bing |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Twenty percent of the genes from Klebsiella pneumonaie MGH78578 coded for hypothetical protein. Two particular hypothetical proteins KPN00728 and KPN00729 were identified using bioinformatics approaches. Both open reading frames showed high sequence homology to succinate dehydrogenase Chain C (SdhC) and D (SdhD) from Escherichia coli KPN00729 was annotated as SdhD in May 2008. Thus, investigation on KPN00728 remained as no annotation for SdhC gene in the complete genome sequence of Klebsiella pneumoniae MGH78578. In this study, KPN00728 has a missing region with conserved residues which is important for
ubiquinone (UQ) and heme group binding. Structure and function prediction of KPN00728 coupled with secondary structure analysis and transmembrane topology showed KPN00728 adopts SDH-(subunit C)-like structure. |
| format | Thesis |
| id | my.usm.eprints.43236 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2011 |
| record_format | eprints |
| spelling | my.usm.eprints.43236 http://eprints.usm.my/43236/ Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies Choi, Sy Bing RS1-441 Pharmacy and materia medica Twenty percent of the genes from Klebsiella pneumonaie MGH78578 coded for hypothetical protein. Two particular hypothetical proteins KPN00728 and KPN00729 were identified using bioinformatics approaches. Both open reading frames showed high sequence homology to succinate dehydrogenase Chain C (SdhC) and D (SdhD) from Escherichia coli KPN00729 was annotated as SdhD in May 2008. Thus, investigation on KPN00728 remained as no annotation for SdhC gene in the complete genome sequence of Klebsiella pneumoniae MGH78578. In this study, KPN00728 has a missing region with conserved residues which is important for ubiquinone (UQ) and heme group binding. Structure and function prediction of KPN00728 coupled with secondary structure analysis and transmembrane topology showed KPN00728 adopts SDH-(subunit C)-like structure. 2011-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43236/1/CHOI%20SY%20BING.pdf Choi, Sy Bing (2011) Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Choi, Sy Bing Structural And Functional Prediction Of Hypothetical Proteins From Klebsiella Pneumoniae MGH78578: Molecular Modelling Studies |
| title | Structural And Functional Prediction Of Hypothetical
Proteins From Klebsiella Pneumoniae MGH78578: Molecular
Modelling Studies |
| title_full | Structural And Functional Prediction Of Hypothetical
Proteins From Klebsiella Pneumoniae MGH78578: Molecular
Modelling Studies |
| title_fullStr | Structural And Functional Prediction Of Hypothetical
Proteins From Klebsiella Pneumoniae MGH78578: Molecular
Modelling Studies |
| title_full_unstemmed | Structural And Functional Prediction Of Hypothetical
Proteins From Klebsiella Pneumoniae MGH78578: Molecular
Modelling Studies |
| title_short | Structural And Functional Prediction Of Hypothetical
Proteins From Klebsiella Pneumoniae MGH78578: Molecular
Modelling Studies |
| title_sort | structural and functional prediction of hypothetical
proteins from klebsiella pneumoniae mgh78578: molecular
modelling studies |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/43236/1/CHOI%20SY%20BING.pdf http://eprints.usm.my/43236/ |
| url_provider | http://eprints.usm.my/ |