Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine
There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS...
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| Format: | Thesis |
| Language: | en |
| Published: |
2010
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| Online Access: | http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf http://eprints.usm.my/41728/ |
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| _version_ | 1834502385679990784 |
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| author | Chitneni , Mallikarjun |
| author_facet | Chitneni , Mallikarjun |
| author_sort | Chitneni , Mallikarjun |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS class IV drugs, namely sulpiride and norfloxacin. Sulpiride is a P-gp substrate and norfloxacin is a
substrate of MRP2, BCRP and an unknown efflux pump. |
| format | Thesis |
| id | my.usm.eprints.41728 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2010 |
| record_format | eprints |
| spelling | my.usm.eprints.41728 http://eprints.usm.my/41728/ Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine Chitneni , Mallikarjun RS1-441 Pharmacy and materia medica There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS class IV drugs, namely sulpiride and norfloxacin. Sulpiride is a P-gp substrate and norfloxacin is a substrate of MRP2, BCRP and an unknown efflux pump. 2010-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf Chitneni , Mallikarjun (2010) Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Chitneni , Mallikarjun Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_full | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_fullStr | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_full_unstemmed | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_short | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_sort | oral bioavailability enhancement of poorly soluble and poorly permeable drugs using self-microemulsifying drug delivery systems and the effect of piperine |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf http://eprints.usm.my/41728/ |
| url_provider | http://eprints.usm.my/ |