Enteric coating of granules containing the probiotic Lactobacillus acidophilus
In the present study, a capsule formulation composed of enteric coated granules of Lactobacillus acidophilus ATCC 4962 was developed using Eudragit L30D-55 as enteric polymer. Optimization of the capsule formulation was achieved with a maximum viable cell count after 2 h of incubation in acid m...
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| Format: | Article |
| Language: | en |
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De Gruyter Open
2014
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| Online Access: | http://eprints.usm.my/38976/1/Enteric_coating_of_granules_containing_the_probiotic_Lactobacillus_acidophilus.pdf http://eprints.usm.my/38976/ https://www.ncbi.nlm.nih.gov/pubmed/24914724 |
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| _version_ | 1834501649678204928 |
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| author | Pyar, Hassan Peh, Kok Khiang |
| author_facet | Pyar, Hassan Peh, Kok Khiang |
| author_sort | Pyar, Hassan |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | In the present study, a capsule formulation composed of
enteric coated granules of Lactobacillus acidophilus ATCC
4962 was developed using Eudragit L30D-55 as enteric
polymer. Optimization of the capsule formulation was
achieved with a maximum viable cell count after 2 h of
incubation in acid medium and disintegration time of 1 h
in buffer pH 6.8. The amount of Eudragit L30D-55 in the
capsules correlated with gastric juice resistance. The best
protective qualities against artificial gastric juice were observed
when capsules were prepared from granules composed
of L. acidophilus, corn starch, lactose monohydrate,
polyvinylpyrrolidone and coated with 12.5 % (m/V) of
Eudragit L30D-55. Capsule formulation of L. acidophilus
in edible broth medium suspension serves as a cheap alternative
to the expensive freeze-drying procedure for preparing
L. acidophilus. In addition, the enteric coating using
Eudragit L30D-55 could protect probiotics from the
acidic gastric environment and enhance the bioactivity
of probiotics along with replacement of pathogenic microbes
in human intestine. |
| format | Article |
| id | my.usm.eprints.38976 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2014 |
| publisher | De Gruyter Open |
| record_format | eprints |
| spelling | my.usm.eprints.38976 http://eprints.usm.my/38976/ Enteric coating of granules containing the probiotic Lactobacillus acidophilus Pyar, Hassan Peh, Kok Khiang RS1-441 Pharmacy and materia medica In the present study, a capsule formulation composed of enteric coated granules of Lactobacillus acidophilus ATCC 4962 was developed using Eudragit L30D-55 as enteric polymer. Optimization of the capsule formulation was achieved with a maximum viable cell count after 2 h of incubation in acid medium and disintegration time of 1 h in buffer pH 6.8. The amount of Eudragit L30D-55 in the capsules correlated with gastric juice resistance. The best protective qualities against artificial gastric juice were observed when capsules were prepared from granules composed of L. acidophilus, corn starch, lactose monohydrate, polyvinylpyrrolidone and coated with 12.5 % (m/V) of Eudragit L30D-55. Capsule formulation of L. acidophilus in edible broth medium suspension serves as a cheap alternative to the expensive freeze-drying procedure for preparing L. acidophilus. In addition, the enteric coating using Eudragit L30D-55 could protect probiotics from the acidic gastric environment and enhance the bioactivity of probiotics along with replacement of pathogenic microbes in human intestine. De Gruyter Open 2014 Article PeerReviewed application/pdf en http://eprints.usm.my/38976/1/Enteric_coating_of_granules_containing_the_probiotic_Lactobacillus_acidophilus.pdf Pyar, Hassan and Peh, Kok Khiang (2014) Enteric coating of granules containing the probiotic Lactobacillus acidophilus. Acta Pharmaceutica, 64 (2). pp. 247-256. ISSN 1330-0075 https://www.ncbi.nlm.nih.gov/pubmed/24914724 |
| spellingShingle | RS1-441 Pharmacy and materia medica Pyar, Hassan Peh, Kok Khiang Enteric coating of granules containing the probiotic Lactobacillus acidophilus |
| title | Enteric coating of granules containing the probiotic
Lactobacillus acidophilus |
| title_full | Enteric coating of granules containing the probiotic
Lactobacillus acidophilus |
| title_fullStr | Enteric coating of granules containing the probiotic
Lactobacillus acidophilus |
| title_full_unstemmed | Enteric coating of granules containing the probiotic
Lactobacillus acidophilus |
| title_short | Enteric coating of granules containing the probiotic
Lactobacillus acidophilus |
| title_sort | enteric coating of granules containing the probiotic
lactobacillus acidophilus |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38976/1/Enteric_coating_of_granules_containing_the_probiotic_Lactobacillus_acidophilus.pdf http://eprints.usm.my/38976/ https://www.ncbi.nlm.nih.gov/pubmed/24914724 |
| url_provider | http://eprints.usm.my/ |