Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats
Colon cancer remains as a serious health problem around the world despite advances in diagnosis and treatment. Dietary fibers are considered to reduce the risk of colon cancer as they are converted to short chain fatty acids by the presence of anaerobic bacteria in the intestine, but imbalanced d...
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2016
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| Online Access: | http://eprints.usm.my/38440/ http://dx.doi.org/10.1016/j.jfda.2015.07.003 |
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| author | Booupathy, Lokesh Kumar Venkatachalam, Sathishkumar Natarajan, Nandakumar Thamaraiselvan, Rengarajan Arumugam, Madankumar Periyasamy, Balasubramanian Maruthaiveeran |
| author_facet | Booupathy, Lokesh Kumar Venkatachalam, Sathishkumar Natarajan, Nandakumar Thamaraiselvan, Rengarajan Arumugam, Madankumar Periyasamy, Balasubramanian Maruthaiveeran |
| author_sort | Booupathy, Lokesh Kumar |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Colon cancer remains as a serious health problem around the world despite advances in
diagnosis and treatment. Dietary fibers are considered to reduce the risk of colon cancer as
they are converted to short chain fatty acids by the presence of anaerobic bacteria in the
intestine, but imbalanced diet and high fat consumption may promote tumor formation at
different sites, including the large bowel via increased bacterial enzymes activity. The
present study was conducted to characterize the inhibitory action of myrtenal on bacterial
enzymes and aberrant crypt foci (ACF). Experimental colon carcinogenesis induced by 1,2-
dimethylhydrazine is histologically, morphologically, and anatomically similar to human
colonic epithelial neoplasm. Discrete microscopic mucosal lesions such as ACF and malignant
tumors function as important biomarkers in the diagnosis of colon cancer. Methylene
blue staining was carried out to visualize the impact of 1,2-dimethylhydrazine and
myrtenal. Myrtenal-treated animals showed decreased levels of bacterial enzymes such as
b-glucuronidase, b-glucosidase, and mucinase. Characteristic changes in the colon were
noticed by inhibiting ACF formation in the colon. |
| format | Article |
| id | my.usm.eprints.38440 |
| institution | Universiti Sains Malaysia |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | my.usm.eprints.38440 http://eprints.usm.my/38440/ Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats Booupathy, Lokesh Kumar Venkatachalam, Sathishkumar Natarajan, Nandakumar Thamaraiselvan, Rengarajan Arumugam, Madankumar Periyasamy, Balasubramanian Maruthaiveeran RB Pathology Colon cancer remains as a serious health problem around the world despite advances in diagnosis and treatment. Dietary fibers are considered to reduce the risk of colon cancer as they are converted to short chain fatty acids by the presence of anaerobic bacteria in the intestine, but imbalanced diet and high fat consumption may promote tumor formation at different sites, including the large bowel via increased bacterial enzymes activity. The present study was conducted to characterize the inhibitory action of myrtenal on bacterial enzymes and aberrant crypt foci (ACF). Experimental colon carcinogenesis induced by 1,2- dimethylhydrazine is histologically, morphologically, and anatomically similar to human colonic epithelial neoplasm. Discrete microscopic mucosal lesions such as ACF and malignant tumors function as important biomarkers in the diagnosis of colon cancer. Methylene blue staining was carried out to visualize the impact of 1,2-dimethylhydrazine and myrtenal. Myrtenal-treated animals showed decreased levels of bacterial enzymes such as b-glucuronidase, b-glucosidase, and mucinase. Characteristic changes in the colon were noticed by inhibiting ACF formation in the colon. Elsevier 2016 Article PeerReviewed Booupathy, Lokesh Kumar and Venkatachalam, Sathishkumar and Natarajan, Nandakumar and Thamaraiselvan, Rengarajan and Arumugam, Madankumar and Periyasamy, Balasubramanian Maruthaiveeran (2016) Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats. Journal of Food and Drug Analysis, 24. pp. 206-213. ISSN 1021-9498 http://dx.doi.org/10.1016/j.jfda.2015.07.003 |
| spellingShingle | RB Pathology Booupathy, Lokesh Kumar Venkatachalam, Sathishkumar Natarajan, Nandakumar Thamaraiselvan, Rengarajan Arumugam, Madankumar Periyasamy, Balasubramanian Maruthaiveeran Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats |
| title | Chemopreventive effect of myrtenal on bacterial
enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats |
| title_full | Chemopreventive effect of myrtenal on bacterial
enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats |
| title_fullStr | Chemopreventive effect of myrtenal on bacterial
enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats |
| title_full_unstemmed | Chemopreventive effect of myrtenal on bacterial
enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats |
| title_short | Chemopreventive effect of myrtenal on bacterial
enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats |
| title_sort | chemopreventive effect of myrtenal on bacterial
enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in wistar rats |
| topic | RB Pathology |
| url | http://eprints.usm.my/38440/ http://dx.doi.org/10.1016/j.jfda.2015.07.003 |
| url_provider | http://eprints.usm.my/ |