Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages: Histopathologist’s Perspective
Much progress has been made since the conceptualization of tumor angiogenesis—the induction of growth of new blood vessels by tumor—as a salient feature of clinically significant primary or metastatic cancers. From a practicing histopathologist’s point of view, we appraise the application of this...
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| Format: | Article |
| Language: | en |
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Hindawi Publishing Corporation
2011
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| Online Access: | http://eprints.usm.my/38409/1/Breast_Tumor_Angiogenesis_and_Tumor-Associated_Macrophages.pdf http://eprints.usm.my/38409/ https://doi.org/10.4061/2011/572706 |
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| author | Ewe, Seng Ch’ng Jaafar, Hasnan Tuan Sharif, Sharifah Emilia |
| author_facet | Ewe, Seng Ch’ng Jaafar, Hasnan Tuan Sharif, Sharifah Emilia |
| author_sort | Ewe, Seng Ch’ng |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Much progress has been made since the conceptualization of tumor angiogenesis—the induction of growth of new blood vessels
by tumor—as a salient feature of clinically significant primary or metastatic cancers. From a practicing histopathologist’s point
of view, we appraise the application of this concept in breast cancer with particular reference to the evaluation of proangiogenic
factors and the assessment of new microvessels in histopathological examination. Recently, much focus has also been centered on
the active roles played by tumor-associated macrophages in relation to tumor angiogenesis. We review the literature; many data
supporting this facet of tumor angiogenesis were derived from the breast cancer models. We scrutinize the large body of clinical
evidence exploring the link between the tumor-associated macrophages and breast tumor angiogenesis and discuss particularly
the methodology and limitations of incorporating such an assessment in histopathological examination. |
| format | Article |
| id | my.usm.eprints.38409 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2011 |
| publisher | Hindawi Publishing Corporation |
| record_format | eprints |
| spelling | my.usm.eprints.38409 http://eprints.usm.my/38409/ Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages: Histopathologist’s Perspective Ewe, Seng Ch’ng Jaafar, Hasnan Tuan Sharif, Sharifah Emilia RB Pathology Much progress has been made since the conceptualization of tumor angiogenesis—the induction of growth of new blood vessels by tumor—as a salient feature of clinically significant primary or metastatic cancers. From a practicing histopathologist’s point of view, we appraise the application of this concept in breast cancer with particular reference to the evaluation of proangiogenic factors and the assessment of new microvessels in histopathological examination. Recently, much focus has also been centered on the active roles played by tumor-associated macrophages in relation to tumor angiogenesis. We review the literature; many data supporting this facet of tumor angiogenesis were derived from the breast cancer models. We scrutinize the large body of clinical evidence exploring the link between the tumor-associated macrophages and breast tumor angiogenesis and discuss particularly the methodology and limitations of incorporating such an assessment in histopathological examination. Hindawi Publishing Corporation 2011 Article PeerReviewed application/pdf en http://eprints.usm.my/38409/1/Breast_Tumor_Angiogenesis_and_Tumor-Associated_Macrophages.pdf Ewe, Seng Ch’ng and Jaafar, Hasnan and Tuan Sharif, Sharifah Emilia (2011) Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages: Histopathologist’s Perspective. Pathology Research International, 2011 (572706). pp. 1-13. ISSN 2090-8091 https://doi.org/10.4061/2011/572706 |
| spellingShingle | RB Pathology Ewe, Seng Ch’ng Jaafar, Hasnan Tuan Sharif, Sharifah Emilia Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages: Histopathologist’s Perspective |
| title | Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages:
Histopathologist’s Perspective |
| title_full | Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages:
Histopathologist’s Perspective |
| title_fullStr | Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages:
Histopathologist’s Perspective |
| title_full_unstemmed | Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages:
Histopathologist’s Perspective |
| title_short | Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages:
Histopathologist’s Perspective |
| title_sort | breast tumor angiogenesis and tumor-associatedmacrophages:
histopathologist’s perspective |
| topic | RB Pathology |
| url | http://eprints.usm.my/38409/1/Breast_Tumor_Angiogenesis_and_Tumor-Associated_Macrophages.pdf http://eprints.usm.my/38409/ https://doi.org/10.4061/2011/572706 |
| url_provider | http://eprints.usm.my/ |