Attributable causes of chronic kidney disease in adults: a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula
CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) is an escalating medical and socioeconomic problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable cause...
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| Format: | Article |
| Language: | en |
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Associação Paulista de Medicina
2015
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| Online Access: | http://eprints.usm.my/38376/1/Attributable_causes_of_chronic_kidney_disease_in_adults.pdf http://eprints.usm.my/38376/ https://www.ncbi.nlm.nih.gov/pubmed/26760124 |
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| author | Salman, Muhammad Hayat Khan, Amer Adnan, Azreen Syazril Syed Sulaiman, Syed Azhar Hussain, Khalid Shehzadi, Naureen Jummaat, Fauziah |
| author_facet | Salman, Muhammad Hayat Khan, Amer Adnan, Azreen Syazril Syed Sulaiman, Syed Azhar Hussain, Khalid Shehzadi, Naureen Jummaat, Fauziah |
| author_sort | Salman, Muhammad |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) is an escalating medical and socioeconomic
problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the
disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable causes of CKD
in an adult population at a tertiary referral hospital.
DESIGN AND SETTING: Retrospective study at Hospital Universiti Sains Malaysia (HUSM).
METHODS: This was an analysis based on medical records of adult patients at HUSM. Data regarding demographics,
laboratory investigations, attributable causes and CKD stage were gathered.
RESULTS: A total of 851 eligible cases were included. The patients’ mean age was 61.18 ± 13.37 years. CKD
stage V was found in 333 cases (39.1%) whereas stages IV, IIIb, IIIa, and II were seen in 240 (28.2%), 186 (21.9%),
74 (8.7%) and 18 (2.1%), respectively. The percentage of CKD stage V patients receiving renal replacement
therapy was 15.6%. The foremost attributable causes of CKD were diabetic nephropathy (DN) (44.9%), hypertension
(HPT) (24.2%) and obstructive uropathy (9.2%). The difference in the prevalence of CKD due to DN,
HPT and glomerulonephritis between patients ≤ 50 and > 50 years old was statistically significant.
CONCLUSION: Our results suggest that DN and HPT are the major attributable causes of CKD among
patients at a Malaysian tertiary-care hospital. Furthermore, the results draw attention to the possibility that
greater emphasis on primary prevention of diabetes and hypertension will have a great impact on reduction
of hospital admissions due to CKD in Malaysia. |
| format | Article |
| id | my.usm.eprints.38376 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2015 |
| publisher | Associação Paulista de Medicina |
| record_format | eprints |
| spelling | my.usm.eprints.38376 http://eprints.usm.my/38376/ Attributable causes of chronic kidney disease in adults: a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula Salman, Muhammad Hayat Khan, Amer Adnan, Azreen Syazril Syed Sulaiman, Syed Azhar Hussain, Khalid Shehzadi, Naureen Jummaat, Fauziah RG Gynecology and obstetrics RS1-441 Pharmacy and materia medica CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) is an escalating medical and socioeconomic problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable causes of CKD in an adult population at a tertiary referral hospital. DESIGN AND SETTING: Retrospective study at Hospital Universiti Sains Malaysia (HUSM). METHODS: This was an analysis based on medical records of adult patients at HUSM. Data regarding demographics, laboratory investigations, attributable causes and CKD stage were gathered. RESULTS: A total of 851 eligible cases were included. The patients’ mean age was 61.18 ± 13.37 years. CKD stage V was found in 333 cases (39.1%) whereas stages IV, IIIb, IIIa, and II were seen in 240 (28.2%), 186 (21.9%), 74 (8.7%) and 18 (2.1%), respectively. The percentage of CKD stage V patients receiving renal replacement therapy was 15.6%. The foremost attributable causes of CKD were diabetic nephropathy (DN) (44.9%), hypertension (HPT) (24.2%) and obstructive uropathy (9.2%). The difference in the prevalence of CKD due to DN, HPT and glomerulonephritis between patients ≤ 50 and > 50 years old was statistically significant. CONCLUSION: Our results suggest that DN and HPT are the major attributable causes of CKD among patients at a Malaysian tertiary-care hospital. Furthermore, the results draw attention to the possibility that greater emphasis on primary prevention of diabetes and hypertension will have a great impact on reduction of hospital admissions due to CKD in Malaysia. Associação Paulista de Medicina 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/38376/1/Attributable_causes_of_chronic_kidney_disease_in_adults.pdf Salman, Muhammad and Hayat Khan, Amer and Adnan, Azreen Syazril and Syed Sulaiman, Syed Azhar and Hussain, Khalid and Shehzadi, Naureen and Jummaat, Fauziah (2015) Attributable causes of chronic kidney disease in adults: a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula. São Paulo Medical Journal, 133 (6). pp. 502-509. ISSN 1516-3180 https://www.ncbi.nlm.nih.gov/pubmed/26760124 |
| spellingShingle | RG Gynecology and obstetrics RS1-441 Pharmacy and materia medica Salman, Muhammad Hayat Khan, Amer Adnan, Azreen Syazril Syed Sulaiman, Syed Azhar Hussain, Khalid Shehzadi, Naureen Jummaat, Fauziah Attributable causes of chronic kidney disease in adults: a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula |
| title | Attributable causes of chronic kidney disease in adults:
a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula |
| title_full | Attributable causes of chronic kidney disease in adults:
a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula |
| title_fullStr | Attributable causes of chronic kidney disease in adults:
a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula |
| title_full_unstemmed | Attributable causes of chronic kidney disease in adults:
a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula |
| title_short | Attributable causes of chronic kidney disease in adults:
a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula |
| title_sort | attributable causes of chronic kidney disease in adults:
a five-year retrospective study in a tertiary-care hospital in the northeast of the malaysian peninsula |
| topic | RG Gynecology and obstetrics RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38376/1/Attributable_causes_of_chronic_kidney_disease_in_adults.pdf http://eprints.usm.my/38376/ https://www.ncbi.nlm.nih.gov/pubmed/26760124 |
| url_provider | http://eprints.usm.my/ |