Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives
A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions.The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv (MTB-H37Rv) and INH-resistant...
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| Format: | Article |
| Language: | en |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://eprints.usm.my/38344/1/Antituberculosis_Synthesis_and_Antimycobacterial_Activity_of_Novel_Benzimidazole_Derivatives.pdf http://eprints.usm.my/38344/ http://dx.doi.org/10.1155/2013/926309 |
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| author | Yeong, Keng Yoon Ali, Mohamed Ashraf Tan, Soo Choon Ismail, Rusli Ang, Chee Wei Kumar, Raju Suresh Osman, Hasnah Beevi, Farzana |
| author_facet | Yeong, Keng Yoon Ali, Mohamed Ashraf Tan, Soo Choon Ismail, Rusli Ang, Chee Wei Kumar, Raju Suresh Osman, Hasnah Beevi, Farzana |
| author_sort | Yeong, Keng Yoon |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under
relatively mild reaction conditions.The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis
H37Rv (MTB-H37Rv) and INH-resistant M. tuberculosis (INHR-MTB) strains using agar dilution method. Three of them
displayed good activity with MIC of less than 0.2 |
| format | Article |
| id | my.usm.eprints.38344 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| record_format | eprints |
| spelling | my.usm.eprints.38344 http://eprints.usm.my/38344/ Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives Yeong, Keng Yoon Ali, Mohamed Ashraf Tan, Soo Choon Ismail, Rusli Ang, Chee Wei Kumar, Raju Suresh Osman, Hasnah Beevi, Farzana QD1-999 Chemistry R735-854 Medical education. Medical schools. Research A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions.The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv (MTB-H37Rv) and INH-resistant M. tuberculosis (INHR-MTB) strains using agar dilution method. Three of them displayed good activity with MIC of less than 0.2 Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/38344/1/Antituberculosis_Synthesis_and_Antimycobacterial_Activity_of_Novel_Benzimidazole_Derivatives.pdf Yeong, Keng Yoon and Ali, Mohamed Ashraf and Tan, Soo Choon and Ismail, Rusli and Ang, Chee Wei and Kumar, Raju Suresh and Osman, Hasnah and Beevi, Farzana (2013) Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives. BioMed Research International, 2013 (926309). pp. 1-6. ISSN 2314-6133 http://dx.doi.org/10.1155/2013/926309 |
| spellingShingle | QD1-999 Chemistry R735-854 Medical education. Medical schools. Research Yeong, Keng Yoon Ali, Mohamed Ashraf Tan, Soo Choon Ismail, Rusli Ang, Chee Wei Kumar, Raju Suresh Osman, Hasnah Beevi, Farzana Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives |
| title | Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives |
| title_full | Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives |
| title_fullStr | Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives |
| title_full_unstemmed | Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives |
| title_short | Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives |
| title_sort | antituberculosis: synthesis and antimycobacterial activity of novel benzimidazole derivatives |
| topic | QD1-999 Chemistry R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/38344/1/Antituberculosis_Synthesis_and_Antimycobacterial_Activity_of_Novel_Benzimidazole_Derivatives.pdf http://eprints.usm.my/38344/ http://dx.doi.org/10.1155/2013/926309 |
| url_provider | http://eprints.usm.my/ |