Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine
Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becomingmore common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice. Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in...
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| Language: | en |
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Hindawi Publishing Corporation
2017
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| Online Access: | http://eprints.usm.my/37014/1/%28Interspecies_In_Vitro_Evaluation%29_8103726.pdf http://eprints.usm.my/37014/ https://doi.org/10.1155/2017/8103726 |
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| _version_ | 1834501115989721088 |
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| author | Wan Aasim, Wan Raihana Soo, Choon Tan Siew, Hua Gan |
| author_facet | Wan Aasim, Wan Raihana Soo, Choon Tan Siew, Hua Gan |
| author_sort | Wan Aasim, Wan Raihana |
| building | Hamzah Sendut Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Malaysia |
| content_source | USM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becomingmore common worldwide. To date, there is no information
available on stereoselectivity of MDMA protein binding in humans, rats, and mice. Since stereoselectivity plays an important role
in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding. The
stereoselective protein binding of rac-MDMA was nvestigated using two different concentrations (20 and 200 ng/mL) in human plasma and mouse and rat sera using an ultrafiltration technique. No significant stereoselectivity in protein binding was observed in both human plasma and rat serum; however, a significant stereoselective binding ( |
| format | Article |
| id | my.usm.eprints.37014 |
| institution | Universiti Sains Malaysia |
| language | en |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| record_format | eprints |
| spelling | my.usm.eprints.37014 http://eprints.usm.my/37014/ Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine Wan Aasim, Wan Raihana Soo, Choon Tan Siew, Hua Gan RS1-441 Pharmacy and materia medica Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becomingmore common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice. Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding. The stereoselective protein binding of rac-MDMA was nvestigated using two different concentrations (20 and 200 ng/mL) in human plasma and mouse and rat sera using an ultrafiltration technique. No significant stereoselectivity in protein binding was observed in both human plasma and rat serum; however, a significant stereoselective binding ( Hindawi Publishing Corporation 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/37014/1/%28Interspecies_In_Vitro_Evaluation%29_8103726.pdf Wan Aasim, Wan Raihana and Soo, Choon Tan and Siew, Hua Gan (2017) Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine. Journal of Chemistry, 2017 (810372). pp. 1-7. ISSN 2090-9063 https://doi.org/10.1155/2017/8103726 |
| spellingShingle | RS1-441 Pharmacy and materia medica Wan Aasim, Wan Raihana Soo, Choon Tan Siew, Hua Gan Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine |
| title | Interspecies In Vitro Evaluation of Stereoselective Protein
Binding for 3,4-Methylenedioxymethamphetamine |
| title_full | Interspecies In Vitro Evaluation of Stereoselective Protein
Binding for 3,4-Methylenedioxymethamphetamine |
| title_fullStr | Interspecies In Vitro Evaluation of Stereoselective Protein
Binding for 3,4-Methylenedioxymethamphetamine |
| title_full_unstemmed | Interspecies In Vitro Evaluation of Stereoselective Protein
Binding for 3,4-Methylenedioxymethamphetamine |
| title_short | Interspecies In Vitro Evaluation of Stereoselective Protein
Binding for 3,4-Methylenedioxymethamphetamine |
| title_sort | interspecies in vitro evaluation of stereoselective protein
binding for 3,4-methylenedioxymethamphetamine |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/37014/1/%28Interspecies_In_Vitro_Evaluation%29_8103726.pdf http://eprints.usm.my/37014/ https://doi.org/10.1155/2017/8103726 |
| url_provider | http://eprints.usm.my/ |