Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis
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| Format: | journal::journal article |
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2024
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| _version_ | 1850176217315016704 |
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| author | Marjanu Hikmah Binti Elias Srijit Das Nazefah Abdul Hamid |
| author_facet | Marjanu Hikmah Binti Elias Srijit Das Nazefah Abdul Hamid |
| author_sort | Marjanu Hikmah Binti Elias |
| building | USIM Library |
| collection | Institutional Repository |
| content_provider | Universiti Sains Islam Malaysia |
| content_source | USIM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Indexed by WOS/Scopus/ERA |
| format | text::journal::journal article |
| id | my.usim.oarep-10708 |
| institution | Universiti Sains Islam Malaysia |
| language | en_US |
| publishDate | 2024 |
| publisher | MDPI |
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| spelling | my.usim.oarep-107082025-11-14T15:56:03Z Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis Marjanu Hikmah Binti Elias Srijit Das Nazefah Abdul Hamid cervical cancer; differentially expressed gene; molecular pathway; gene ontology Indexed by WOS/Scopus/ERA Cervical cancer is the leading cause of cancer-related death among women in developing countries. However, no comprehensive molecular mechanism for cervical cancer has been established, as many studies were small-cohort studies conducted with small sample sizes. A thorough literature search was performed using the PubMed, Scopus, EBSCOhost, and Science Direct databases. Medical Subject Heading (MeSH) terms such as “Uterine Cervical Neoplasms” and “gene expression” were used as the keywords in all fields. A total of 4027 studies were retrieved, and only clinical studies, which used the microarray method to identify differentially expressed genes (DEGs) in the cervical tissue of cervical cancer patients, were selected. Following the screening, 6 studies were selected and 1128 DEGs were extracted from the data. Sixty-two differentially expressed genes from at least two studies were selected for further analysis by DAVID, STRING, and Cytoscape software. In cervical cancer pathogenesis, three significant clusters with high intermolecular interactions from the Protein–Protein Interaction (PPI) network complex revealed three major molecular mechanisms, including cell signaling, cell cycle, and cell differentiation. Subsequently, eight genes were chosen as the candidate genes based on their involvement in the relevant gene ontology (GO) and their interaction with other genes in the PPI network through undirected first neighbor nodes. The present systematic review improves our understanding of the molecular mechanism of cervical cancer and the proposed genes that can be used to expand the biomarker panel in the screening for cervical cancer. The targeted genes may be beneficial for the development of better treatment strategies. 2024-05-29T02:27:39Z 2024-05-29T02:27:39Z 2023 2023-4-19 text::journal::journal article Elias, M.H.; Das, S.; Abdul Hamid, N. Candidate Genes and Pathways in Cervical Cancer: A Systematic Review and Integrated Bioinformatic Analysis. Cancers 2023, 15, 853. https://doi.org/10.3390/ cancers15030853 2072-6694 10.3390/cancers15030853 https://www.mdpi.com/2072-6694/15/3/853#metrics https://oarep.usim.edu.my/handle/123456789/10708 1 13 2023 15 en_US Cancers application/pdf MDPI |
| spellingShingle | cervical cancer; differentially expressed gene; molecular pathway; gene ontology Marjanu Hikmah Binti Elias Srijit Das Nazefah Abdul Hamid Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis |
| title | Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis |
| title_full | Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis |
| title_fullStr | Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis |
| title_full_unstemmed | Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis |
| title_short | Candidate Genes And Pathways In The Cervical Cancer: A Systematic Review And Integrated Bioinformatic Analysis |
| title_sort | candidate genes and pathways in the cervical cancer: a systematic review and integrated bioinformatic analysis |
| topic | cervical cancer; differentially expressed gene; molecular pathway; gene ontology |
| url_provider | http://oarep.usim.edu.my/ |