Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

Epicardial formation is necessary for normal myocardial morphogenesis. Here, we show that differentiating hiPSC-derived lateral plate mesoderm with BMP4, RA and VEGF (BVR) can generate a premature form of epicardial cells (termed pre-epicardial cells, PECs) expressing WT1, TBX18, SEMA3D, and SCX wit...

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Main Authors:	Tan, Jun Jie, Guyette, Jacques P., Miki, Kenji, Xiao, Ling, Kaur, Gurbani, Wu, Tong, Zhu, Liye, Hansen, Katrina J., Ling, King Hwa, Milan, David J., Ott, Harald C.
Format:	Article
Language:	en
Published:	Nature Publishing 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/97567/1/ABSTRACT.pdf http://psasir.upm.edu.my/id/eprint/97567/ https://www.nature.com/articles/s41467-021-24921-z
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