Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice
Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar prod...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Nature Publishing Group
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/60889/1/Anti-obesity%20and%20anti-inflammatory%20effects%20of%20synthetic%20acetic%20acid%20vinegar%20and%20Nipa%20vinegar%20on%20high-fat-diet-induced%20obese%20mice.pdf http://psasir.upm.edu.my/id/eprint/60889/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532206/pdf/41598_2017_Article_6235.pdf |
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| Summary: | Recently, food-based bioactive ingredients, such as vinegar, have been proposed as a potential solution to overcome the global obesity epidemic. Although acetic acid has been identified as the main component in vinegar that contributes to its anti-obesity effect, reports have shown that vinegar produced from different starting materials possess different degrees of bioactivity. This study was performed to compare the anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar in mice fed a high-fat diet. In this work, mice were fed a high-fat diet for 33 weeks. At the start of week 24, obese mice were orally fed synthetic acetic acid vinegar or Nipa vinegar (0.08 and 2 ml/kg BW) until the end of week 33. Mice fed a standard pellet diet served as a control. Although both synthetic acetic acid vinegar and Nipa vinegar effectively reduced food intake and body weight, a high dose of Nipa vinegar more effectively reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice. Thus, a high dose of Nipa vinegar may potentially alleviate obesity by altering the lipid metabolism, inflammation and gut microbe composition in high-fat-diet-induced obese mice. |
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