Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study
A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for...
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| Format: | Article |
| Language: | en English |
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Bentham Science Publishers
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/5821/1/Synthesis%20of%20Glutamate.pdf http://psasir.upm.edu.my/id/eprint/5821/ http://dx.doi.org/10.2174/157341308786306161 |
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| _version_ | 1832511045267095552 |
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| author | Md Ajat, Mohd Mokrish Yusoff, Khatijah Hussein, Mohd Zobir |
| author_facet | Md Ajat, Mohd Mokrish Yusoff, Khatijah Hussein, Mohd Zobir |
| author_sort | Md Ajat, Mohd Mokrish |
| building | UPM Library |
| collection | Institutional Repository |
| content_provider | Universiti Putra Malaysia |
| content_source | UPM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for further characterization. BINH exhibits the glutamate to be in vertical or perpendicular orientation to the inorganic layer. Cytotoxicty test indicates that the IC50 value was observed at 3.125 μg/ml. Results from this study will be used in the development of a new delivery system for therapeutic agents comprising amino acids or peptides. |
| format | Article |
| id | my.upm.eprints-5821 |
| institution | Universiti Putra Malaysia |
| language | en English |
| publishDate | 2008 |
| publisher | Bentham Science Publishers |
| record_format | eprints |
| spelling | my.upm.eprints-58212015-10-26T00:56:40Z http://psasir.upm.edu.my/id/eprint/5821/ Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study Md Ajat, Mohd Mokrish Yusoff, Khatijah Hussein, Mohd Zobir A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for further characterization. BINH exhibits the glutamate to be in vertical or perpendicular orientation to the inorganic layer. Cytotoxicty test indicates that the IC50 value was observed at 3.125 μg/ml. Results from this study will be used in the development of a new delivery system for therapeutic agents comprising amino acids or peptides. Bentham Science Publishers 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/5821/1/Synthesis%20of%20Glutamate.pdf Md Ajat, Mohd Mokrish and Yusoff, Khatijah and Hussein, Mohd Zobir (2008) Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study. Current Nanoscience, 4 (4). pp. 391-396. ISSN 1573-4137 http://dx.doi.org/10.2174/157341308786306161 10.2174/157341308786306161 English |
| spellingShingle | Md Ajat, Mohd Mokrish Yusoff, Khatijah Hussein, Mohd Zobir Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study |
| title | Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study |
| title_full | Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study |
| title_fullStr | Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study |
| title_full_unstemmed | Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study |
| title_short | Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study |
| title_sort | synthesis of glutamate-zinc-aluminium-layered double hydroxide nanobiocomposites and cell viability study |
| url | http://psasir.upm.edu.my/id/eprint/5821/1/Synthesis%20of%20Glutamate.pdf http://psasir.upm.edu.my/id/eprint/5821/ http://dx.doi.org/10.2174/157341308786306161 |
| url_provider | http://psasir.upm.edu.my/ |