Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol–gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform i...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
The Institution of Engineering and Technology
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/52109/1/Characterisation%20of%20sol%E2%80%93gel%20method%20synthesised%20MgZnFe2O4%20nanoparticles%20and%20its%20cytotoxic%20effects%20on%20breast%20cancer%20cell%20line%2C%20MDA%20MB-231%20in%20vitro.pdf http://psasir.upm.edu.my/id/eprint/52109/ http://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2016.0007 |
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| Summary: | In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol–gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscopy revealed that the average particle size of the calcined sample was in a range of 17–41 nm with an average of 29 nm and has spherical size. A cytotoxicity test was performed on human breast cancer cells (MDA MB-231) and (MCF-7) at various concentrations starting from (0 µg/ml) to (800 µg/ml). The sample possessed a mild toxic effect toward MDA MB-231 and MCF-7 after being examined with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay for up to 72 h of incubation. Higher reduction of cells viability was observed as the concentration of sample was increased in MDA MB-231 cell line than in MCF-7. Therefore, further cytotoxicity tests were performed on MDA MB-231 cell line. |
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