Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica
2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-?-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the root...
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| Format: | Article |
| Language: | en en |
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Taylor & Francis
2000
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40321/1/Antiviral%2C%20cyototoxic%20and%20antimicrobial%20activities%20of%20anthraquinones%20isolated%20from%20the%20roots%20of%20Morinda%20elliptica.pdf http://psasir.upm.edu.my/id/eprint/40321/7/Antiviral%20%20Cyototoxic%20And%20Antimicrobial%20Activities%20Of%20Anthraquinones%20Isolated%20From%20The%20Roots%20Of%20Morinda%20Elliptica.pdf http://psasir.upm.edu.my/id/eprint/40321/ http://www.tandfonline.com/doi/abs/10.1076/1388-0209%28200009%293841-AFT298#.VeZfV5drsZM |
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| author | Ali, Abdul Manaf Ismail, Nor Hadiani Mohamed Mackeen, Muhammad Mukram Saiful Yazan, Latifah Mohamed, S. M. Ho, A. S. H. Lajis, Nordin |
| author_facet | Ali, Abdul Manaf Ismail, Nor Hadiani Mohamed Mackeen, Muhammad Mukram Saiful Yazan, Latifah Mohamed, S. M. Ho, A. S. H. Lajis, Nordin |
| author_sort | Ali, Abdul Manaf |
| building | UPM Library |
| collection | Institutional Repository |
| content_provider | Universiti Putra Malaysia |
| content_source | UPM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | 2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-?-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the roots of Morinda elliptica , were assayed for anti-HIV, cytotoxic and antimicrobial activites. Only damnacanthal showed moderate activity against HIV. It was cytotoxic towards the MCF-7 (breast carcinoma) and CEM-SS (T-lymphoblastic leukaemia) cell line. Nordamnacanthal was very cytotoxic against the CEM-SS cell lines. Other anthraquinones that showed strong cytotoxicity towards the cell lines tested were lucidin-?-methyl ether (CEM-SS and MCF-7) and rubiadin (CEM-SS). Three anthraquinones viz., nordamnacanthal, damnacanthal and morindone, were found to have strong antimicrobial activity. |
| format | Article |
| id | my.upm.eprints-40321 |
| institution | Universiti Putra Malaysia |
| language | en en |
| publishDate | 2000 |
| publisher | Taylor & Francis |
| record_format | eprints |
| spelling | my.upm.eprints-403212024-07-23T06:54:21Z http://psasir.upm.edu.my/id/eprint/40321/ Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica Ali, Abdul Manaf Ismail, Nor Hadiani Mohamed Mackeen, Muhammad Mukram Saiful Yazan, Latifah Mohamed, S. M. Ho, A. S. H. Lajis, Nordin 2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-?-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the roots of Morinda elliptica , were assayed for anti-HIV, cytotoxic and antimicrobial activites. Only damnacanthal showed moderate activity against HIV. It was cytotoxic towards the MCF-7 (breast carcinoma) and CEM-SS (T-lymphoblastic leukaemia) cell line. Nordamnacanthal was very cytotoxic against the CEM-SS cell lines. Other anthraquinones that showed strong cytotoxicity towards the cell lines tested were lucidin-?-methyl ether (CEM-SS and MCF-7) and rubiadin (CEM-SS). Three anthraquinones viz., nordamnacanthal, damnacanthal and morindone, were found to have strong antimicrobial activity. Taylor & Francis 2000 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/40321/1/Antiviral%2C%20cyototoxic%20and%20antimicrobial%20activities%20of%20anthraquinones%20isolated%20from%20the%20roots%20of%20Morinda%20elliptica.pdf text en http://psasir.upm.edu.my/id/eprint/40321/7/Antiviral%20%20Cyototoxic%20And%20Antimicrobial%20Activities%20Of%20Anthraquinones%20Isolated%20From%20The%20Roots%20Of%20Morinda%20Elliptica.pdf Ali, Abdul Manaf and Ismail, Nor Hadiani and Mohamed Mackeen, Muhammad Mukram and Saiful Yazan, Latifah and Mohamed, S. M. and Ho, A. S. H. and Lajis, Nordin (2000) Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica. Pharmaceutical Biology, 38 (4). pp. 298-301. ISSN 1388-0209; ESSN: 1744-5116 http://www.tandfonline.com/doi/abs/10.1076/1388-0209%28200009%293841-AFT298#.VeZfV5drsZM 10.1076/1388-0209(200009)3841-AFT298 |
| spellingShingle | Ali, Abdul Manaf Ismail, Nor Hadiani Mohamed Mackeen, Muhammad Mukram Saiful Yazan, Latifah Mohamed, S. M. Ho, A. S. H. Lajis, Nordin Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica |
| title | Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica |
| title_full | Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica |
| title_fullStr | Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica |
| title_full_unstemmed | Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica |
| title_short | Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica |
| title_sort | antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of morinda elliptica |
| url | http://psasir.upm.edu.my/id/eprint/40321/1/Antiviral%2C%20cyototoxic%20and%20antimicrobial%20activities%20of%20anthraquinones%20isolated%20from%20the%20roots%20of%20Morinda%20elliptica.pdf http://psasir.upm.edu.my/id/eprint/40321/7/Antiviral%20%20Cyototoxic%20And%20Antimicrobial%20Activities%20Of%20Anthraquinones%20Isolated%20From%20The%20Roots%20Of%20Morinda%20Elliptica.pdf http://psasir.upm.edu.my/id/eprint/40321/ http://www.tandfonline.com/doi/abs/10.1076/1388-0209%28200009%293841-AFT298#.VeZfV5drsZM |
| url_provider | http://psasir.upm.edu.my/ |