Phytochemical screening of Ayer Hitam Forest Reserve : Isolation of Ariskanin-A from Thottea corymbosa (Griff.) Ding Hou (Aristolochiaceae)
During a phytochemical screening of higher plants at Ayer Hitam Forest Reserve, Puchong, Selangor, we collected a large amount of sample of Thottea corymbosa roots for further investigation of its bioactive constituents. The plant is a shrub commonly used in herbal medicine and could easily be fou...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Universiti Putra Malaysia Press
2001
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| Online Access: | http://psasir.upm.edu.my/id/eprint/3313/1/Phytochemical_Screening_of_Ayer_Hitam_Forest_Reserve__Isolation_of.pdf http://psasir.upm.edu.my/id/eprint/3313/ http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2024%20(1)%20Apr.%202001/12%20JTAS%20Vol.24%20(1)%202001%20(Pg%2053-55).pdf |
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| Summary: | During a phytochemical screening of higher plants at Ayer Hitam Forest Reserve, Puchong, Selangor, we collected
a large amount of sample of Thottea corymbosa roots for further investigation of its bioactive constituents. The
plant is a shrub commonly used in herbal medicine and could easily be found along the open forest trails. The
roots of the collected sample were consecutively extracted with petroleum-ether, chloroform and methanol followed
by separation of the chloroform fraction by column chromatography and preparative thin-layer chromatography.
In this study we reported the isolation of an aristolactam, Ariskanin-A with a toxicity value of LC50 <200 ppm
in Brine-Shrimp Lethality Bioassay based on spectroscopic data and comparison with literature. |
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