Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models.
Moringa oleifera L. (Moringaceae) is known to possess high nutritional value and is used in a folklore medicine to treat various ailments related to pain and inflammation. The aim of the present study was to evaluate the antinoCICeptive and anti-inflammatory effects of the aqueous extract of the lea...
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| Format: | Article |
| Language: | English |
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Informa Healthcare
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14607/ |
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| author | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Bujarimin, A. S. Somchit, Muhammad Nazrul Hakim Israf Ali, Daud Ahmad Moin, Saidi |
| author_facet | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Bujarimin, A. S. Somchit, Muhammad Nazrul Hakim Israf Ali, Daud Ahmad Moin, Saidi |
| author_sort | Sulaiman, Mohd Roslan |
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| content_provider | Universiti Putra Malaysia |
| content_source | UPM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Moringa oleifera L. (Moringaceae) is known to possess high nutritional value and is used in a folklore medicine to treat various ailments related to pain and inflammation. The aim of the present study was to evaluate the antinoCICeptive and anti-inflammatory effects of the aqueous extract of the leaves of M. oleifera in laboratory animals, using the writhing, hot-plate and formalin tests as the antinoCICeptive assays, and carrageenan-induced paw edema test as the anti-inflammatory assay. The extract (10, 30 and 100 mg/kg) exhibited significant (P < 0.05) antinoCICeptive activity, which occurred in a dose-dependent manner, in all tests used. The extract also exhibited significant (P < 0.05) anti-inflammatory activity in a dose-dependent manner. Furthermore, the extract antinoCICeptive activity was suggested to be modulated via opioid receptors at the central, but not peripheral, antinoCICeptive level, based on the ability of 5 mg/kg naloxone to reverse the extract activity in the hot-plate, but not the writhing test. In conclusion, M. oleifera leaves possess peripherally non-opioid mediated and centrally opioid mediated antinoCICeptive and anti-inflammtory activities. This study also confirms the traditional uses of M. oleifera in the treatment of ailments, particularly those related to pain and inflammation. |
| format | Article |
| id | my.upm.eprints-14607 |
| institution | Universiti Putra Malaysia |
| language | English |
| publishDate | 2008 |
| publisher | Informa Healthcare |
| record_format | eprints |
| spelling | my.upm.eprints-146072013-11-11T03:13:49Z http://psasir.upm.edu.my/id/eprint/14607/ Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Bujarimin, A. S. Somchit, Muhammad Nazrul Hakim Israf Ali, Daud Ahmad Moin, Saidi Moringa oleifera L. (Moringaceae) is known to possess high nutritional value and is used in a folklore medicine to treat various ailments related to pain and inflammation. The aim of the present study was to evaluate the antinoCICeptive and anti-inflammatory effects of the aqueous extract of the leaves of M. oleifera in laboratory animals, using the writhing, hot-plate and formalin tests as the antinoCICeptive assays, and carrageenan-induced paw edema test as the anti-inflammatory assay. The extract (10, 30 and 100 mg/kg) exhibited significant (P < 0.05) antinoCICeptive activity, which occurred in a dose-dependent manner, in all tests used. The extract also exhibited significant (P < 0.05) anti-inflammatory activity in a dose-dependent manner. Furthermore, the extract antinoCICeptive activity was suggested to be modulated via opioid receptors at the central, but not peripheral, antinoCICeptive level, based on the ability of 5 mg/kg naloxone to reverse the extract activity in the hot-plate, but not the writhing test. In conclusion, M. oleifera leaves possess peripherally non-opioid mediated and centrally opioid mediated antinoCICeptive and anti-inflammtory activities. This study also confirms the traditional uses of M. oleifera in the treatment of ailments, particularly those related to pain and inflammation. Informa Healthcare 2008 Article PeerReviewed Sulaiman, Mohd Roslan and Zakaria, Zainul Amiruddin and Bujarimin, A. S. and Somchit, Muhammad Nazrul Hakim and Israf Ali, Daud Ahmad and Moin, Saidi (2008) Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. Pharmaceutical Biology, 46 (12). pp. 838-845. ISSN 1388-0209; ESSN: 1744-5116 10.1080/13880200802366710 English |
| spellingShingle | Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Bujarimin, A. S. Somchit, Muhammad Nazrul Hakim Israf Ali, Daud Ahmad Moin, Saidi Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. |
| title | Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. |
| title_full | Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. |
| title_fullStr | Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. |
| title_full_unstemmed | Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. |
| title_short | Evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. |
| title_sort | evaluation of moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. |
| url | http://psasir.upm.edu.my/id/eprint/14607/ |
| url_provider | http://psasir.upm.edu.my/ |