Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf
Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30,...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Informatics Publishing Limited and Natural Remedies
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13148/1/Anti-inflammatory.pdf http://psasir.upm.edu.my/id/eprint/13148/ http://www.informaticsjournals.com/index.php/jnr/article/view/249 |
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| Summary: | Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30, 100 and 300 mg/kg when administered orally. It is also demonstrated that the intraperitoneal administration of AML at a dose of 30, 100 and 300 mg/kg produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dose dependent manner. These results indicate that AML exhibits significant anti-inflammatory and antinociceptive effects. |
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