The CRL4Cdt2 E3 ubiquitin ligase: a comprehensive review of its substrates, mechanisms, and roles in genomic stability

The CRL4Cdt2 ubiquitin ligase complex plays a pivotal role in maintaining genomic integrity and regulating the cell cycle, specifically during the S phase. By targeting key proteins such as Cdt1, p21, and Set8 for ubiquitination and degradation, CRL4Cdt2 ensures proper DNA replication and cell cycle...

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Main Authors:	Murba, Afiqah Aimie, Ibrahim, Muhammad Aidil, Zakaria, Sarah Shazwani, Adenan, Nurul Hidayah, Jamaludin, Mohamad Ikhwan, Nishitani, Hideo, Ali, Mohd Shukuri Mohamad, Mazian, Mu’adz Ahmad
Format:	Article
Language:	en
Published:	University of Malaya 2026
Subjects:	Biotechnology Molecular Biology
Online Access:	http://psasir.upm.edu.my/id/eprint/124276/1/124276.pdf http://psasir.upm.edu.my/id/eprint/124276/ https://www.msmbb.my/images/publication/volume_34/issue_1/01-Murba-et-al.pdf
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