Gamma-ray irradiation differentially modulates PD-1 and CTLA-4 expression and tumour growth in parental and acquired radioresistant EMT6 mouse models

Background: Immune checkpoint proteins such as PD-1 and CTLA-4 play pivotal roles in tumour immune evasion. Our previous in vitro studies demonstrated upregulation of Pdcd1 and Ctla4 mRNA in the acquired radioresistant murine breast cancer cell line EMT6RR_MJI . This study aimed to evaluate their ge...

Full description

Bibliographic Details

Main Authors:	V Sham, Nur Fatihah, Hasani, Narimah Abdul Hamid, Hasbullah, Harissa Husainy, Wan Mohamad Zain, Wan Nor I’zzah, Hasan, Nurhaslina, Othman, Suraya, Osman, Nora Julianna, Abdul Karim, Muhammad Khalis, Syed Ahmad Fuad, Syed Baharom, Ibahim, Mohammad Johari
Format:	Article
Language:	en
Published:	BiomedPress 2026
Subjects:	Medicine (all) Biochemistry, Genetics and Molecular Biology (all)
Online Access:	http://psasir.upm.edu.my/id/eprint/123575/1/123575.pdf http://psasir.upm.edu.my/id/eprint/123575/ https://bmrat.org/index.php/BMRAT/article/view/1038
Tags:	Add Tag No Tags, Be the first to tag this record!