Total-body PET/CT metabolic response in esophageal squamous cell carcinoma

Total-body PET/CT metabolic response in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) exhibits heterogeneous responses to neoadjuvant therapy, necessitating early and accurate assessment. [18F]fluorodeoxyglucose ([18F]FDG) PET/CT enables quantitative assessment of tumor glucose metabolism, correlating with pathological remission and long-term...

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Main Authors: Yang, Runjun, Lu, Xinyi, Tang, Wenxin, Nardo, Lorenzo, Xie, Yunze, Al-Ibraheem, Akram, Zhang, Lichao, Zhao, Wenjin, Rominger, Axel, Tan, Lijie, Tang, Han, Muhammad Fuad, Ida Nur Syafinaz, Suppiah, Subapriya, Cruz, Eric, Lin, Yu, Yu, Haojun, Shi, Hongcheng
Format: Article
Language:en
Published: W.B. Saunders 2026
Subjects:
Radiology, Nuclear Medicine and Imaging
Online Access:http://psasir.upm.edu.my/id/eprint/123385/1/123385.pdf
http://psasir.upm.edu.my/id/eprint/123385/
https://www.sciencedirect.com/science/article/pii/S000129982500162X
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Summary:Esophageal squamous cell carcinoma (ESCC) exhibits heterogeneous responses to neoadjuvant therapy, necessitating early and accurate assessment. [18F]fluorodeoxyglucose ([18F]FDG) PET/CT enables quantitative assessment of tumor glucose metabolism, correlating with pathological remission and long-term outcomes, while [18F] or [68Ga]Ga-labeled fibroblast activation protein inhibitor (FAPI) PET/CT evaluates stromal metabolism, providing complementary information. Total-body PET/CT (uEXPLORER, United Imaging Healthcare Co.Ltd., Shanghai, China) with 194-cm long-axial field-of-view (LAFOV) offers long axial coverage, up to 68-fold higher sensitivity than conventional systems. It enables low-dose, rapid imaging, dynamic whole-body parametric imaging, and improves detection of small, low-uptake lesions as well as metastatic lesions in the distal upper or lower extremities in a single bed position. Delayed and dual-time imaging protocols, alone and/or combined with deep learning–based synthetic CT, further improve lesion detectability while minimizing radiation exposure. This narrative review summarizes evidence from conventional PET/CT studies, highlights the technical and clinical advantages of total-body PET/CT, and discusses its feasibility, quantitative capabilities, and potential to guide response-adapted management in ESCC based on our institutional experience.

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