A novel plant‑based approach for synthesis of iron oxide nanoparticles and cancer therapy
Cancer remains a major challenge in modern medicine, often hindered by the limitations of conventional treatments such as chemotherapy, including severe side effects and low specificity. Iron oxide nanoparticles (IONPs) have emerged as promising tools for cancer theranostics, owing to their magnet...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Springer Science and Business Media LLC
2025
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/123217/1/123217.pdf http://psasir.upm.edu.my/id/eprint/123217/ https://link.springer.com/article/10.1007/s44371-025-00091-5 |
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| Summary: | Cancer remains a major challenge in modern medicine, often hindered by the limitations of conventional treatments
such as chemotherapy, including severe side effects and low specificity. Iron oxide nanoparticles (IONPs) have emerged
as promising tools for cancer theranostics, owing to their magnetic responsiveness, tunable surface properties, and ability
to enhance both therapeutic and diagnostic precision. This review focuses on the advancements in the green synthesis
of IONPs using plant extracts rich in polyphenols, which serve as natural reducing agents while providing additional
anti-cancer benefits. These green-synthesized IONPs demonstrate potential in targeted drug delivery, controlled release,
and enhanced imaging through magnetic resonance imaging (MRI), offering a sustainable and effective approach to
cancer treatment. The review highlights the biosafety, biocompatibility, and anticancer efficacy of green-synthesized
IONPs through an in-depth analysis of preclinical in vitro studies from the last five years. Key challenges in plant-based
synthesis, such as reproducibility and variability in phytochemical composition, are critically discussed alongside strategies to address these limitations. Furthermore, using waste materials in green synthesis is emphasized as a sustainable
approach to nanoparticle production, promoting resource efficiency and environmental stewardship. This comprehensive analysis underscores the dual functionality of green-synthesized IONPs as a novel, eco-friendly solution for cancer
theranostics, paving the way for sustainable and scalable applications in future biomedical research. |
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